Synergistic activity of colistin plus rifampin against colistin-resistant kpc-producing klebsiella pneumoniae

Carlo Tascini; Enrico Tagliaferri; Tommaso Giani; Alessandro Leonildi; Sarah Flammini; Beatrice Casini; Russell Lewis; Simone Ferranti; Gian Maria Rossolini; Francesco Menichetti

doi:10.1128/AAC.00179-13

Synergistic activity of colistin plus rifampin against colistin-resistant kpc-producing klebsiella pneumoniae

Carlo Tascini, Enrico Tagliaferri, Tommaso Giani, Alessandro Leonildi, Sarah Flammini, Beatrice Casini, Russell Lewis, Simone Ferranti, Gian Maria Rossolini, Francesco Menichetti

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Infections caused by carbapenem-resistant KPC-producing Klebsiella pneumoniae are responsible for high rates of mortality and represent a major therapeutic challenge, especially when the isolates are also resistant to colistin. We used the checkerboard method to evaluate the synergistic activity of 10 antibiotic combinations against 13 colistin-resistant KPC-producing K. pneumoniae isolates (colistin MIC range of 8 to 128 mg/liter). Colistin plus rifampin was the only combination that demonstrated consistent synergistic bacteriostatic activity against 13/13 strains tested, reducing the colistin MIC below the susceptibility breakpoint (MIC

Original language	English
Pages (from-to)	3990-3993
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00179-13
Publication status	Published - Aug 2013

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology
Infectious Diseases

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Synergistic activity of colistin plus rifampin against colistin-resistant kpc-producing klebsiella pneumoniae. / Tascini, Carlo; Tagliaferri, Enrico; Giani, Tommaso; Leonildi, Alessandro; Flammini, Sarah; Casini, Beatrice; Lewis, Russell; Ferranti, Simone; Rossolini, Gian Maria; Menichetti, Francesco.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 8, 08.2013, p. 3990-3993.

Research output: Contribution to journal › Article › peer-review

Tascini, Carlo ; Tagliaferri, Enrico ; Giani, Tommaso ; Leonildi, Alessandro ; Flammini, Sarah ; Casini, Beatrice ; Lewis, Russell ; Ferranti, Simone ; Rossolini, Gian Maria ; Menichetti, Francesco. / Synergistic activity of colistin plus rifampin against colistin-resistant kpc-producing klebsiella pneumoniae. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 8. pp. 3990-3993.

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