Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

Judith Michels; Ilio Vitale; Laura Senovilla; David P. Enot; Pauline Garcia; Delphine Lissa; Ken A. Olaussen; Catherine Brenner; Jean Charles Soria; Maria Castedo; Guido Kroemer

doi:10.4161/cc.24034

Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

Judith Michels, Ilio Vitale, Laura Senovilla, David P. Enot, Pauline Garcia, Delphine Lissa, Ken A. Olaussen, Catherine Brenner, Jean Charles Soria, Maria Castedo, Guido Kroemer

Istituto Regina Elena

Research output: Contribution to journal › Article

Abstract

Abbreviations: CDDP, cisplatin; CEP, CEP 8983; DiOC6(3), 3′-dihexyloxacarbocyanine iodide; Δψm, mitochondrial transmembrane potential; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; NSCLC, non-small cell lung carcinoma; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; PJ, PJ34 hydrochloride hydrate; siRNA, small-interfering RNA.

Original language	English
Pages (from-to)	877-883
Number of pages	7
Journal	Cell Cycle
Volume	12
Issue number	6
DOIs	https://doi.org/10.4161/cc.24034
Publication status	Published - Mar 15 2013

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Keywords

A549 cells
Apoptosis
CEP 8983
DNA damage response
PJ34 hydrochloride
Small-interfering RNAd

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Developmental Biology

Cite this

Michels, J., Vitale, I., Senovilla, L., Enot, D. P., Garcia, P., Lissa, D., Olaussen, K. A., Brenner, C., Soria, J. C., Castedo, M., & Kroemer, G. (2013). Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer. Cell Cycle, 12(6), 877-883. https://doi.org/10.4161/cc.24034

Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer. / Michels, Judith; Vitale, Ilio; Senovilla, Laura; Enot, David P.; Garcia, Pauline; Lissa, Delphine; Olaussen, Ken A.; Brenner, Catherine; Soria, Jean Charles; Castedo, Maria; Kroemer, Guido.

In: Cell Cycle, Vol. 12, No. 6, 15.03.2013, p. 877-883.

Research output: Contribution to journal › Article

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Access to Document

10.4161/cc.24034