Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

Judith Michels; Ilio Vitale; Laura Senovilla; David P. Enot; Pauline Garcia; Delphine Lissa; Ken A. Olaussen; Catherine Brenner; Jean Charles Soria; Maria Castedo; Guido Kroemer

doi:10.4161/cc.24034

Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

Judith Michels, Ilio Vitale, Laura Senovilla, David P. Enot, Pauline Garcia, Delphine Lissa, Ken A. Olaussen, Catherine Brenner, Jean Charles Soria, Maria Castedo, Guido Kroemer

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Abbreviations: CDDP, cisplatin; CEP, CEP 8983; DiOC6(3), 3′-dihexyloxacarbocyanine iodide; Δψm, mitochondrial transmembrane potential; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; NSCLC, non-small cell lung carcinoma; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; PJ, PJ34 hydrochloride hydrate; siRNA, small-interfering RNA.

Original language	English
Pages (from-to)	877-883
Number of pages	7
Journal	Cell Cycle
Volume	12
Issue number	6
DOIs	https://doi.org/10.4161/cc.24034
Publication status	Published - Mar 15 2013

Keywords

A549 cells
Apoptosis
CEP 8983
DNA damage response
PJ34 hydrochloride
Small-interfering RNAd

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Developmental Biology

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10.4161/cc.24034

Cite this

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title = "Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer",

abstract = "Abbreviations: CDDP, cisplatin; CEP, CEP 8983; DiOC6(3), 3′-dihexyloxacarbocyanine iodide; Δψm, mitochondrial transmembrane potential; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; NSCLC, non-small cell lung carcinoma; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; PJ, PJ34 hydrochloride hydrate; siRNA, small-interfering RNA.",

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T1 - Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

AU - Michels, Judith

AU - Vitale, Ilio

AU - Senovilla, Laura

AU - Enot, David P.

AU - Garcia, Pauline

AU - Lissa, Delphine

AU - Olaussen, Ken A.

AU - Brenner, Catherine

AU - Soria, Jean Charles

AU - Castedo, Maria

AU - Kroemer, Guido

PY - 2013/3/15

Y1 - 2013/3/15

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AB - Abbreviations: CDDP, cisplatin; CEP, CEP 8983; DiOC6(3), 3′-dihexyloxacarbocyanine iodide; Δψm, mitochondrial transmembrane potential; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; NSCLC, non-small cell lung carcinoma; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; PJ, PJ34 hydrochloride hydrate; siRNA, small-interfering RNA.

KW - A549 cells

KW - Apoptosis

KW - CEP 8983

KW - DNA damage response

KW - PJ34 hydrochloride

KW - Small-interfering RNAd

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Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

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