Synergistic interactions between kainate and mGlu receptors regulate bouton Ca 2+ signalling and mossy fibre LTP

Robert Nisticó, Sheila L. Dargan, Mascia Amici, Graham L. Collingridge, Zuner A. Bortolotto

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15 Citations (Scopus)

Abstract

It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu 1 and mGlu 5 receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the pharmacological activation of either mGlu 1 or mGlu 5 receptors, provided that kainate receptors are also stimulated. Like conventional mossy fibre LTP, chemically-induced mossy fibre LTP (chem-LTPm) depends on Ca 2+ release from intracellular stores and the activation of PKA. Similar synergistic interactions between mGlu receptors and kainate receptors were observed at the level of Ca 2+ signalling in individual giant mossy fibre boutons. Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain.

Original languageEnglish
Article number103
JournalScientific Reports
Volume1
DOIs
Publication statusPublished - 2011

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Kainic Acid Receptors
Glutamate Receptors
Presynaptic Terminals
Hippocampus
Pharmacology
Brain

ASJC Scopus subject areas

  • General

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Synergistic interactions between kainate and mGlu receptors regulate bouton Ca 2+ signalling and mossy fibre LTP. / Nisticó, Robert; Dargan, Sheila L.; Amici, Mascia; Collingridge, Graham L.; Bortolotto, Zuner A.

In: Scientific Reports, Vol. 1, 103, 2011.

Research output: Contribution to journalArticle

Nisticó, Robert ; Dargan, Sheila L. ; Amici, Mascia ; Collingridge, Graham L. ; Bortolotto, Zuner A. / Synergistic interactions between kainate and mGlu receptors regulate bouton Ca 2+ signalling and mossy fibre LTP. In: Scientific Reports. 2011 ; Vol. 1.
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