Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation

Gianluigi Condorelli, Antonio Giordano

Research output: Contribution to journalArticlepeer-review


In this review, the complex relationship between tissue-specific transcription factors and genes regulating cell cycle is taken into account. Both E1-A binding proteins belonging to the family of the retinoblastoma gene product and the CBP/p300 coactivator of transcription interact physically and functionally with tissue-specific transcription factor. The relationship between these two classes of molecules regulates cell fate in differentiating cells, deciding whether cells continue to replicate, undergo apoptosis or terminally differentiate. We provide here an update on the recent advances in this field and some models of interaction between E1A binding protein and tissue-specific transcription factors.

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalJournal of Cellular Biochemistry
Issue number4
Publication statusPublished - Dec 15 1997


  • Differentiation
  • DNA tumor viruses
  • E1A-binding proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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