Syngeneic murine metastasis models: B16 melanoma

Raffaella Giavazzi, Alessandra Decio

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

The murine B16 melanoma is one of the most used tumor models, its application having been used to determine the mechanisms associated with the metastatic process and the development of anticancer therapies. The B16 melanoma was originally established by Fidler and collaborators as a tumor line metastasizing to the lung. Since that time a variety of cell lines have been derived, in vitro or in vivo, having different metastatic behaviors. The methods used to obtain artificial metastases to the lung through the intravenous injection of B16 melanoma cells and spontaneous metastasis formation following cancer cell growth in the footpad are described in this chapter.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages131-140
Number of pages10
Volume1070
ISBN (Print)9781461482437
DOIs
Publication statusPublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1070
ISSN (Print)10643745

Fingerprint

Experimental Melanomas
Neoplasm Metastasis
Neoplasms
Lung
Intravenous Injections
Cell Line
Growth
Therapeutics

Keywords

  • B16 melanoma
  • Imaging techniques
  • Lung colonies
  • Metastatic process
  • Spontaneous metastasis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Giavazzi, R., & Decio, A. (2014). Syngeneic murine metastasis models: B16 melanoma. In Methods in Molecular Biology (Vol. 1070, pp. 131-140). (Methods in Molecular Biology; Vol. 1070). Humana Press Inc.. https://doi.org/10.1007/978-1-4614-8244-4_10

Syngeneic murine metastasis models : B16 melanoma. / Giavazzi, Raffaella; Decio, Alessandra.

Methods in Molecular Biology. Vol. 1070 Humana Press Inc., 2014. p. 131-140 (Methods in Molecular Biology; Vol. 1070).

Research output: Chapter in Book/Report/Conference proceedingChapter

Giavazzi, R & Decio, A 2014, Syngeneic murine metastasis models: B16 melanoma. in Methods in Molecular Biology. vol. 1070, Methods in Molecular Biology, vol. 1070, Humana Press Inc., pp. 131-140. https://doi.org/10.1007/978-1-4614-8244-4_10
Giavazzi R, Decio A. Syngeneic murine metastasis models: B16 melanoma. In Methods in Molecular Biology. Vol. 1070. Humana Press Inc. 2014. p. 131-140. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4614-8244-4_10
Giavazzi, Raffaella ; Decio, Alessandra. / Syngeneic murine metastasis models : B16 melanoma. Methods in Molecular Biology. Vol. 1070 Humana Press Inc., 2014. pp. 131-140 (Methods in Molecular Biology).
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