Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose

S. Persiani, R. Rotini, G. Trisolino, L. C. Rovati, M. Locatelli, D. Paganini, D. Antonioli, A. Roda

Research output: Contribution to journalArticle

Abstract

Objective: We investigated the synovial and plasma glucosamine concentrations in osteoarthritic patients following oral administration of crystalline glucosamine sulphate at the therapeutic dose of 1500 mg once-a-day for 14 days. Design: Twelve osteoarthritic patients (six males and six females) received 14 consecutive once-daily oral administrations of crystalline glucosamine sulphate soluble powder (1500 mg), in an open fashion. Plasma and synovial fluid were collected simultaneously from the same patient, at baseline and, at steady state (3 h after the last dose). Glucosamine was determined in plasma and synovial fluid by liquid chromatography-tandem mass spectrometry. Results: Median endogenous glucosamine concentrations in plasma and synovial fluid were 52.0 ng/ml (0.29 μM) and 36.5 ng/ml (0.21 μM), respectively (P = 0.001), and varied substantially among patients (41-121 ng/ml and

Original languageEnglish
Pages (from-to)764-772
Number of pages9
JournalOsteoarthritis and Cartilage
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Bioavailability
  • Glucosamine sulphate
  • Human
  • Mechanism of action
  • Synovial fluid

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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