Abstract
Background: European protocols for paediatric synovial sarcoma (SS) require that all children routinely undergo chest computed tomography (CT) scanning and bone scanning as initial staging procedures. This study aims to determine the rate of initial metastases in paediatric SS based on specific clinical characteristics, thereby investigating whether these diagnostic procedures are really necessary in all patients. Methods: Data on 258 previously-untreated SS patients 5 cm than for tumours ≤5 cm. Conclusions: Our findings suggest that tumour diameter can be used as a variable for identifying patients at greater risk of metastases and warranting more accurate radiological investigations. Chest CT scanning may improve the accuracy of pulmonary staging over X-ray, but requires different ionising radiation exposures that might have carcinogenic potential: it can be omitted for patients with tumours ≤5 cm. Given the very low risk of bone metastases, bone scans may be recommended only in cases with evidence of lung metastases.
Original language | English |
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Pages (from-to) | 1370-1375 |
Number of pages | 6 |
Journal | European Journal of Cancer |
Volume | 48 |
Issue number | 9 |
DOIs | |
Publication status | Published - Jun 2012 |
Keywords
- Bone scan
- Computed tomography
- Lung metastases
- Paediatric sarcoma
- Radiation exposure
- Staging
- Synovial sarcoma
ASJC Scopus subject areas
- Cancer Research
- Oncology