Sarcoma sinoviale in età pediatrica. Esperienza dell'Istituto Nazionale Tumori, Milano

Translated title of the contribution: Synovial sarcoma in children. Experience of the Istituto Nazionale Tumori, Milano

Research output: Contribution to journalArticle

Abstract

Objectives. Multimodality treatment approach has improved the prognosis of synovial sarcoma during the last two decades, but the real role of post-operative radiotherapy and adjuvant chemotherapy remains to be determined. Methods. Thirty-five children affected by synovial sarcoma were treated at our Pediatric Oncology Unit during a 25-year period: among the 34 patients with localized disease, 18 had radical surgery (2 amputation, 12 primary re-excision), 14 non-radical resection, 2 biopsy. Radiotherapy was delivered to 22 patients, chemotherapy to 31. Results. Twenty-nine patients were alive, 24 in first complete remission. With a median follow-up of 10 years, survival was 86.1% at 5 years. In univariate analysis, tumor size, local invasiveness and site of origin were the significant prognostic factors. Conclusions. In comparison to adults', childhood synovial sarcoma seems to have a more favorable outcome, probably related to the systematic use of chemotherapy and radiotherapy in the treatment programs. The pivotal role of surgery remains unquestionable. Radiotherapy seems advisable in patients considered at high risk due to size, local invasiveness and non-radical surgery. Pediatric protocols require the use of chemotherapy in all patients.

Original languageItalian
Pages (from-to)869-875
Number of pages7
JournalItalian Journal of Pediatrics
Volume27
Issue number6
Publication statusPublished - Dec 2001

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Synovial Sarcoma
Radiotherapy
Drug Therapy
Pediatrics
Adjuvant Chemotherapy
Amputation
Biopsy
Survival
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{f493849f391e40f4aeeb8cff3155b47a,
title = "Sarcoma sinoviale in et{\`a} pediatrica. Esperienza dell'Istituto Nazionale Tumori, Milano",
abstract = "Objectives. Multimodality treatment approach has improved the prognosis of synovial sarcoma during the last two decades, but the real role of post-operative radiotherapy and adjuvant chemotherapy remains to be determined. Methods. Thirty-five children affected by synovial sarcoma were treated at our Pediatric Oncology Unit during a 25-year period: among the 34 patients with localized disease, 18 had radical surgery (2 amputation, 12 primary re-excision), 14 non-radical resection, 2 biopsy. Radiotherapy was delivered to 22 patients, chemotherapy to 31. Results. Twenty-nine patients were alive, 24 in first complete remission. With a median follow-up of 10 years, survival was 86.1{\%} at 5 years. In univariate analysis, tumor size, local invasiveness and site of origin were the significant prognostic factors. Conclusions. In comparison to adults', childhood synovial sarcoma seems to have a more favorable outcome, probably related to the systematic use of chemotherapy and radiotherapy in the treatment programs. The pivotal role of surgery remains unquestionable. Radiotherapy seems advisable in patients considered at high risk due to size, local invasiveness and non-radical surgery. Pediatric protocols require the use of chemotherapy in all patients.",
keywords = "Pediatric malignancies, Soft-tissue sarcoma, Synovial sarcoma",
author = "A. Ferrari and C. Meazza and M. Casanova and R. Luksch and F. Spreafico and M. Massimino and M. Terenziani and D. Polastri and G. Cefalo and L. Gandola and A. Gronchi and {Fossati Bellani}, F.",
year = "2001",
month = "12",
language = "Italian",
volume = "27",
pages = "869--875",
journal = "Italian Journal of Pediatrics",
issn = "1720-8424",
publisher = "BioMed Central Ltd.",
number = "6",

}

TY - JOUR

T1 - Sarcoma sinoviale in età pediatrica. Esperienza dell'Istituto Nazionale Tumori, Milano

AU - Ferrari, A.

AU - Meazza, C.

AU - Casanova, M.

AU - Luksch, R.

AU - Spreafico, F.

AU - Massimino, M.

AU - Terenziani, M.

AU - Polastri, D.

AU - Cefalo, G.

AU - Gandola, L.

AU - Gronchi, A.

AU - Fossati Bellani, F.

PY - 2001/12

Y1 - 2001/12

N2 - Objectives. Multimodality treatment approach has improved the prognosis of synovial sarcoma during the last two decades, but the real role of post-operative radiotherapy and adjuvant chemotherapy remains to be determined. Methods. Thirty-five children affected by synovial sarcoma were treated at our Pediatric Oncology Unit during a 25-year period: among the 34 patients with localized disease, 18 had radical surgery (2 amputation, 12 primary re-excision), 14 non-radical resection, 2 biopsy. Radiotherapy was delivered to 22 patients, chemotherapy to 31. Results. Twenty-nine patients were alive, 24 in first complete remission. With a median follow-up of 10 years, survival was 86.1% at 5 years. In univariate analysis, tumor size, local invasiveness and site of origin were the significant prognostic factors. Conclusions. In comparison to adults', childhood synovial sarcoma seems to have a more favorable outcome, probably related to the systematic use of chemotherapy and radiotherapy in the treatment programs. The pivotal role of surgery remains unquestionable. Radiotherapy seems advisable in patients considered at high risk due to size, local invasiveness and non-radical surgery. Pediatric protocols require the use of chemotherapy in all patients.

AB - Objectives. Multimodality treatment approach has improved the prognosis of synovial sarcoma during the last two decades, but the real role of post-operative radiotherapy and adjuvant chemotherapy remains to be determined. Methods. Thirty-five children affected by synovial sarcoma were treated at our Pediatric Oncology Unit during a 25-year period: among the 34 patients with localized disease, 18 had radical surgery (2 amputation, 12 primary re-excision), 14 non-radical resection, 2 biopsy. Radiotherapy was delivered to 22 patients, chemotherapy to 31. Results. Twenty-nine patients were alive, 24 in first complete remission. With a median follow-up of 10 years, survival was 86.1% at 5 years. In univariate analysis, tumor size, local invasiveness and site of origin were the significant prognostic factors. Conclusions. In comparison to adults', childhood synovial sarcoma seems to have a more favorable outcome, probably related to the systematic use of chemotherapy and radiotherapy in the treatment programs. The pivotal role of surgery remains unquestionable. Radiotherapy seems advisable in patients considered at high risk due to size, local invasiveness and non-radical surgery. Pediatric protocols require the use of chemotherapy in all patients.

KW - Pediatric malignancies

KW - Soft-tissue sarcoma

KW - Synovial sarcoma

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