Synovial sarcoma of children and adolescents: The prognostic role of axial sites

Andrea Ferrari, Gianni Bisogno, Rita Alaggio, Giovanni Cecchetto, Paola Collini, Angelo Rosolen, Cristina Meazza, Paolo Indolfi, Alberto Garaventa, Luigi De Sio, Paolo D'Angelo, Paolo Tamaro, Michela Casanova, Modesto Carli

Research output: Contribution to journalArticle

Abstract

Background: The outcome of patients with non-extremity synovial sarcoma (SS) is generally worse than that of patients with limb tumours. Methods: The present study analysed a series of 115 consecutive SS patients treated in Italian paediatric protocols (period 1979-2005), mainly focusing on the 30 cases arising from 'axial' sites (16 head-neck, 8 trunk, 4 lung-pleura and 2 retroperitoneum). Results: Initial gross resection was achieved in 40% of axial cases and in 80% of limb SS (p <0.0001). Five-year EFS and overall survival (OS) were, respectively, 43.3% and 55.1% for axial SS, and 69.6% (p = 0.0068) and 84.0% (p = 0.0004) for extremity SS. Local progression/recurrence was the cause of treatment failure in 75% of relapsing patients axial disease. Conclusions: Our findings emphasise that children and adolescents with SS originating at non-extremity locations have a worse prognosis than those with limb SS. Tumour site should be considered when defining a risk-adapted treatment strategy for SS.

Original languageEnglish
Pages (from-to)1202-1209
Number of pages8
JournalEuropean Journal of Cancer
Volume44
Issue number9
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Axial sites
  • Childhood soft tissue sarcomas
  • Non-rhabdomyosarcoma soft tissue sarcomas
  • Prognostic factors
  • Synovial sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Ferrari, A., Bisogno, G., Alaggio, R., Cecchetto, G., Collini, P., Rosolen, A., Meazza, C., Indolfi, P., Garaventa, A., De Sio, L., D'Angelo, P., Tamaro, P., Casanova, M., & Carli, M. (2008). Synovial sarcoma of children and adolescents: The prognostic role of axial sites. European Journal of Cancer, 44(9), 1202-1209. https://doi.org/10.1016/j.ejca.2008.03.016