TY - JOUR
T1 - Synovial tissue heterogeneity and peripheral blood biomarkers
AU - Bugatti, Serena
AU - Manzo, Antonio
AU - Bombardieri, Michele
AU - Vitolo, Barbara
AU - Humby, Frances
AU - Kelly, Stephen
AU - Montecucco, Carlomaurizio
AU - Pitzalis, Costantino
PY - 2011/10
Y1 - 2011/10
N2 - Rheumatoid arthritis is characterized by multiple pathobiological processes and heterogeneous clinical phenotypes. Not surprisingly, the inflamed synovium harbors an equally complex pathology. This includes variability in infiltrating and resident cell populations, spatial arrangements, and cell-cell interactions, as well as gene expression profiles. Remarkable progress in our understanding of the many facets of tissue heterogeneity has been facilitated by the increasing availability of patients' material and the development of advanced research technologies. The next challenge is to capitalize on the large amount of data generated to elucidate the specific pathogenic pathways disparately activated in different patients and/or different phases of the disease. When tissue pathology can be reliably explored through noninvasive circulating biomarkers, then the circle will be closed. We attempt to highlight key advances in the understanding of synovial tissue heterogeneity in rheumatoid arthritis and summarize novel perspectives in synovial biomarker discovery in relation to peripheral blood.
AB - Rheumatoid arthritis is characterized by multiple pathobiological processes and heterogeneous clinical phenotypes. Not surprisingly, the inflamed synovium harbors an equally complex pathology. This includes variability in infiltrating and resident cell populations, spatial arrangements, and cell-cell interactions, as well as gene expression profiles. Remarkable progress in our understanding of the many facets of tissue heterogeneity has been facilitated by the increasing availability of patients' material and the development of advanced research technologies. The next challenge is to capitalize on the large amount of data generated to elucidate the specific pathogenic pathways disparately activated in different patients and/or different phases of the disease. When tissue pathology can be reliably explored through noninvasive circulating biomarkers, then the circle will be closed. We attempt to highlight key advances in the understanding of synovial tissue heterogeneity in rheumatoid arthritis and summarize novel perspectives in synovial biomarker discovery in relation to peripheral blood.
KW - Biomarker
KW - Heterogeneity
KW - Peripheral blood
KW - Rheumatoid arthritis
KW - Synovial membrane
KW - Synovial tissue
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U2 - 10.1007/s11926-011-0201-y
DO - 10.1007/s11926-011-0201-y
M3 - Article
C2 - 21847543
AN - SCOPUS:80755172249
VL - 13
SP - 440
EP - 448
JO - Current Rheumatology Reports
JF - Current Rheumatology Reports
SN - 1523-3774
IS - 5
ER -