Synthesis & antitumor activity of new group 3 Metallocene complexes

Angelamaria Caporale, Giuseppe Palma, Annaluisa Mariconda, Vitale Del Vecchio, Domenico Iacopetta, Ortensia Ilaria Parisi, Maria Stefania Sinicropi, Francesco Puoci, Claudio Arra, Pasquale Longo, Carmela Saturnino

Research output: Contribution to journalArticlepeer-review

Abstract

The quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy.

Original languageEnglish
Article number526
JournalMolecules
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Breast cancer
  • Cell membrane permeability
  • Cytotoxic activity
  • Metal complexes
  • Metallocene group 3
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)
  • Organic Chemistry

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