Synthesis and μ-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives

D. Barlocco, G. Cignarella, P. Vianello, S. Villa, G. A. Pinna, P. Fadda, W. Fratta

Research output: Contribution to journalArticle

Abstract

A new series of analogues (1c-j; 2c-i) of the previously reported analgesic 3,8-diazabicyclo[3.2.1]octanes (1a,b; 2a,b) was synthesized and tested for their affinity towards μ-opioid receptors. Modifications were introduced either at the cinnamyl or the acyl side chains. The majority of the new compounds, with the exception of 1c,j and 2c, showed K(i) values better or comparable with those of the models.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalFarmaco
Volume53
Issue number8-9
DOIs
Publication statusPublished - Aug 30 1998

Keywords

  • Analgesic activity
  • Diazabicyclooctane
  • Opioid receptors

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Synthesis and μ-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives'. Together they form a unique fingerprint.

  • Cite this