Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines

M. Anzini, A. Cappelli, S. Vomero, G. Campiani, A. Cagnotto, M. Skorupska

Research output: Contribution to journalArticlepeer-review

Abstract

The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.

Original languageEnglish
Pages (from-to)1435-1447
Number of pages13
JournalFarmaco
Volume46
Issue number12
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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