Synthesis and activity of new linear and cyclic peptide T derivatives

M. Marastoni, S. Salvadori, V. Scaranari, S. Spisani, E. Reali, S. Traniello, A. Tomatis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Linear and head to tail cyclic hexapeptide analogs (Xaa-Thr-Thr-Asn-Tyr-Thr, Xaa = D-Asp or D-iso-Asp) of peptide T were prepared and tested for human monocyte chemotaxis. All new compounds showed significant bioactivity. In particular, the conformational restriction introduced into cyclo(-D-iso-Asp-Thr-Thr-Asn-Tyr-Thr-) was very suitable for CD4 receptor binding. The cyclic peptides also proved to be highly resistant to degradation by plasma or brain enzymes.

Original languageEnglish
Pages (from-to)1073-1076
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume44
Issue number9
Publication statusPublished - 1994

Fingerprint

Peptide T
Cyclic Peptides
CD4 Antigens
Chemotaxis
Bioactivity
Monocytes
Brain
Derivatives
Plasmas
Degradation
Enzymes

Keywords

  • human immunodeficiency virus
  • peptide T analogs, biodegradation, chemotactic activity, synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Marastoni, M., Salvadori, S., Scaranari, V., Spisani, S., Reali, E., Traniello, S., & Tomatis, A. (1994). Synthesis and activity of new linear and cyclic peptide T derivatives. Arzneimittel-Forschung/Drug Research, 44(9), 1073-1076.

Synthesis and activity of new linear and cyclic peptide T derivatives. / Marastoni, M.; Salvadori, S.; Scaranari, V.; Spisani, S.; Reali, E.; Traniello, S.; Tomatis, A.

In: Arzneimittel-Forschung/Drug Research, Vol. 44, No. 9, 1994, p. 1073-1076.

Research output: Contribution to journalArticle

Marastoni, M, Salvadori, S, Scaranari, V, Spisani, S, Reali, E, Traniello, S & Tomatis, A 1994, 'Synthesis and activity of new linear and cyclic peptide T derivatives', Arzneimittel-Forschung/Drug Research, vol. 44, no. 9, pp. 1073-1076.
Marastoni M, Salvadori S, Scaranari V, Spisani S, Reali E, Traniello S et al. Synthesis and activity of new linear and cyclic peptide T derivatives. Arzneimittel-Forschung/Drug Research. 1994;44(9):1073-1076.
Marastoni, M. ; Salvadori, S. ; Scaranari, V. ; Spisani, S. ; Reali, E. ; Traniello, S. ; Tomatis, A. / Synthesis and activity of new linear and cyclic peptide T derivatives. In: Arzneimittel-Forschung/Drug Research. 1994 ; Vol. 44, No. 9. pp. 1073-1076.
@article{ee9fced2a2654f16acac3c740a27e3fb,
title = "Synthesis and activity of new linear and cyclic peptide T derivatives",
abstract = "Linear and head to tail cyclic hexapeptide analogs (Xaa-Thr-Thr-Asn-Tyr-Thr, Xaa = D-Asp or D-iso-Asp) of peptide T were prepared and tested for human monocyte chemotaxis. All new compounds showed significant bioactivity. In particular, the conformational restriction introduced into cyclo(-D-iso-Asp-Thr-Thr-Asn-Tyr-Thr-) was very suitable for CD4 receptor binding. The cyclic peptides also proved to be highly resistant to degradation by plasma or brain enzymes.",
keywords = "human immunodeficiency virus, peptide T analogs, biodegradation, chemotactic activity, synthesis",
author = "M. Marastoni and S. Salvadori and V. Scaranari and S. Spisani and E. Reali and S. Traniello and A. Tomatis",
year = "1994",
language = "English",
volume = "44",
pages = "1073--1076",
journal = "Arzneimittel-Forschung/Drug Research",
issn = "0004-4172",
publisher = "Editio Cantor Verlag GmbH",
number = "9",

}

TY - JOUR

T1 - Synthesis and activity of new linear and cyclic peptide T derivatives

AU - Marastoni, M.

AU - Salvadori, S.

AU - Scaranari, V.

AU - Spisani, S.

AU - Reali, E.

AU - Traniello, S.

AU - Tomatis, A.

PY - 1994

Y1 - 1994

N2 - Linear and head to tail cyclic hexapeptide analogs (Xaa-Thr-Thr-Asn-Tyr-Thr, Xaa = D-Asp or D-iso-Asp) of peptide T were prepared and tested for human monocyte chemotaxis. All new compounds showed significant bioactivity. In particular, the conformational restriction introduced into cyclo(-D-iso-Asp-Thr-Thr-Asn-Tyr-Thr-) was very suitable for CD4 receptor binding. The cyclic peptides also proved to be highly resistant to degradation by plasma or brain enzymes.

AB - Linear and head to tail cyclic hexapeptide analogs (Xaa-Thr-Thr-Asn-Tyr-Thr, Xaa = D-Asp or D-iso-Asp) of peptide T were prepared and tested for human monocyte chemotaxis. All new compounds showed significant bioactivity. In particular, the conformational restriction introduced into cyclo(-D-iso-Asp-Thr-Thr-Asn-Tyr-Thr-) was very suitable for CD4 receptor binding. The cyclic peptides also proved to be highly resistant to degradation by plasma or brain enzymes.

KW - human immunodeficiency virus

KW - peptide T analogs, biodegradation, chemotactic activity, synthesis

UR - http://www.scopus.com/inward/record.url?scp=0028674512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028674512&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 1073

EP - 1076

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

SN - 0004-4172

IS - 9

ER -