Synthesis and activity of new linear and cyclic peptide T derivatives

M. Marastoni, S. Salvadori, V. Scaranari, S. Spisani, E. Reali, S. Traniello, A. Tomatis

Research output: Contribution to journalArticle

Abstract

Linear and head to tail cyclic hexapeptide analogs (Xaa-Thr-Thr-Asn-Tyr-Thr, Xaa = D-Asp or D-iso-Asp) of peptide T were prepared and tested for human monocyte chemotaxis. All new compounds showed significant bioactivity. In particular, the conformational restriction introduced into cyclo(-D-iso-Asp-Thr-Thr-Asn-Tyr-Thr-) was very suitable for CD4 receptor binding. The cyclic peptides also proved to be highly resistant to degradation by plasma or brain enzymes.

Original languageEnglish
Pages (from-to)1073-1076
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume44
Issue number9
Publication statusPublished - 1994

Keywords

  • human immunodeficiency virus
  • peptide T analogs, biodegradation, chemotactic activity, synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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  • Cite this

    Marastoni, M., Salvadori, S., Scaranari, V., Spisani, S., Reali, E., Traniello, S., & Tomatis, A. (1994). Synthesis and activity of new linear and cyclic peptide T derivatives. Arzneimittel-Forschung/Drug Research, 44(9), 1073-1076.