Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones

Angela Scala, Massimiliano Cordaro, Antonino Mazzaglia, Francesco Risitano, Assunta Venuti, Maria Teresa Sciortino, Giovanni Grassi

Research output: Contribution to journalArticlepeer-review

Abstract

A novel class of water soluble indole-3,4-diones has been synthesized and evaluated in vitro for antiviral activity against HSV-1. The results showed lack of cytotoxicity and significant antiviral activity. The cellular internalization efficiency and the antiherpetic effect were successfully increased by incorporation into nanoaggregates of an amphiphilic β-cyclodextrin.

Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalMedChemComm
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2011

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

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