Abstract
| Original language | English |
|---|---|
| Article number | e1800177 |
| Journal | Archiv der Pharmazie |
| Volume | 351 |
| DOIs | |
| Publication status | Published - 2018 |
Fingerprint
Cite this
Synthesis and antimycobacterial activity of (+)-usnic acid conjugates. / Cirillo, D; Borroni, E; Festoso, I; Monti, D; Romeo, S; Mazier, D; Verotta, L.
In: Archiv der Pharmazie, Vol. 351, e1800177, 2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and antimycobacterial activity of (+)-usnic acid conjugates
AU - Cirillo, D
AU - Borroni, E
AU - Festoso, I
AU - Monti, D
AU - Romeo, S
AU - Mazier, D
AU - Verotta, L
PY - 2018
Y1 - 2018
N2 - New therapeutics are urgently needed to fight tuberculosis and mycobacteria-related diseases that are a major health hazard especially in poor countries. Natural products have been the source of important antitubercular drugs in the past and still need to receive attention as a potent reservoir of chemical structures. Fifteen known and two new (+)-usnic acid (a benzofurandione formerly isolated from lichens) enamines and hydrazones are here described and tested against sensitive and multidrug-resistant strains of mycobacteria. Among several (+)-usnic acid conjugates, PS14 and PS18 showed potent activity against both susceptible and resistant Mycobacterium tuberculosis strains (MIC values of 1–32 and 2–32 mg/L, respectively) comparable with MIC of other antitubercular drugs already in use for tuberculosis treatment. © 2018 Deutsche Pharmazeutische Gesellschaft
AB - New therapeutics are urgently needed to fight tuberculosis and mycobacteria-related diseases that are a major health hazard especially in poor countries. Natural products have been the source of important antitubercular drugs in the past and still need to receive attention as a potent reservoir of chemical structures. Fifteen known and two new (+)-usnic acid (a benzofurandione formerly isolated from lichens) enamines and hydrazones are here described and tested against sensitive and multidrug-resistant strains of mycobacteria. Among several (+)-usnic acid conjugates, PS14 and PS18 showed potent activity against both susceptible and resistant Mycobacterium tuberculosis strains (MIC values of 1–32 and 2–32 mg/L, respectively) comparable with MIC of other antitubercular drugs already in use for tuberculosis treatment. © 2018 Deutsche Pharmazeutische Gesellschaft
U2 - 10.1002/ardp.201800177
DO - 10.1002/ardp.201800177
M3 - Article
VL - 351
JO - Archiv der Pharmazie
JF - Archiv der Pharmazie
SN - 0365-6233
M1 - e1800177
ER -