Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives

Hanan Sekkak, Souad Mojahidi, El Mostapha Rakib, Said Abouricha, Abdelali Kerbal, Cinzia Aiello, Maurizio Viale

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The 1,3-dipolar cycloaddition of N-aryl-C-ethoxycarbonylnitrile imines to pyridazin-3-thione afforded novel spirothiadiazolopyridazines in moderate to good yields. The reaction occurs regioselectively at the exocyclic C=S bond. Some of the newly synthesized compounds were tested for their in vitro antitumor activity against three human and murine cell lines [human: A2780, (ovary, carcinoma), A549 (lung, carcinoma); murine: P388 (leukaemia)]. Among the series, some compounds exhibited significant growth inhibitory effects against cell lines P388.

Original languageEnglish
Pages (from-to)743-746
Number of pages4
JournalLetters in Drug Design and Discovery
Volume7
Issue number10
Publication statusPublished - Dec 2010

Fingerprint

Leukemia P388
Carcinoma
Thiones
Cell Line
Imines
Cycloaddition Reaction
Ovary
Lung
Growth
In Vitro Techniques

Keywords

  • Cytotoxic activity.
  • Pyridazinethione
  • Spirothiadiazolopyridazine

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

Cite this

Sekkak, H., Mojahidi, S., Rakib, E. M., Abouricha, S., Kerbal, A., Aiello, C., & Viale, M. (2010). Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives. Letters in Drug Design and Discovery, 7(10), 743-746.

Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives. / Sekkak, Hanan; Mojahidi, Souad; Rakib, El Mostapha; Abouricha, Said; Kerbal, Abdelali; Aiello, Cinzia; Viale, Maurizio.

In: Letters in Drug Design and Discovery, Vol. 7, No. 10, 12.2010, p. 743-746.

Research output: Contribution to journalArticle

Sekkak, H, Mojahidi, S, Rakib, EM, Abouricha, S, Kerbal, A, Aiello, C & Viale, M 2010, 'Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives', Letters in Drug Design and Discovery, vol. 7, no. 10, pp. 743-746.
Sekkak H, Mojahidi S, Rakib EM, Abouricha S, Kerbal A, Aiello C et al. Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives. Letters in Drug Design and Discovery. 2010 Dec;7(10):743-746.
Sekkak, Hanan ; Mojahidi, Souad ; Rakib, El Mostapha ; Abouricha, Said ; Kerbal, Abdelali ; Aiello, Cinzia ; Viale, Maurizio. / Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives. In: Letters in Drug Design and Discovery. 2010 ; Vol. 7, No. 10. pp. 743-746.
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