Synthesis and antiproliferative evaluation of spirothiadiazolopyridazine derivatives

Hanan Sekkak, Souad Mojahidi, El Mostapha Rakib, Said Abouricha, Abdelali Kerbal, Cinzia Aiello, Maurizio Viale

Research output: Contribution to journalArticlepeer-review

Abstract

The 1,3-dipolar cycloaddition of N-aryl-C-ethoxycarbonylnitrile imines to pyridazin-3-thione afforded novel spirothiadiazolopyridazines in moderate to good yields. The reaction occurs regioselectively at the exocyclic C=S bond. Some of the newly synthesized compounds were tested for their in vitro antitumor activity against three human and murine cell lines [human: A2780, (ovary, carcinoma), A549 (lung, carcinoma); murine: P388 (leukaemia)]. Among the series, some compounds exhibited significant growth inhibitory effects against cell lines P388.

Original languageEnglish
Pages (from-to)743-746
Number of pages4
JournalLetters in Drug Design and Discovery
Volume7
Issue number10
Publication statusPublished - Dec 2010

Keywords

  • Cytotoxic activity.
  • Pyridazinethione
  • Spirothiadiazolopyridazine

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

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