A series of 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-1-one derivatives and related compounds were tested for their ability to bind benzodiazepine receptors (BZRs). Most of the synthesized compounds showed micromolar affinity for BZR peripheral type, but not for the central one, with the exception of compound 4m which displayed an IC50=0.407 μM, only 2 fold higher than IC50 for chlordiazepoxide.
|Number of pages||12|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Drug Discovery
- Pharmaceutical Science