Synthesis and benzodiazepine receptors affinity of 2,3-dihydro-9-phenyl- 1H-pyrrolo[3,4-b]quinolin-1-one and 3-carbethoxy-4-phenylquinoline derivatives

M. Anzini, A. Cappelli, S. Vomero, A. Cagnotto, M. Skorupska

Research output: Contribution to journalArticlepeer-review

Abstract

A series of 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-1-one derivatives and related compounds were tested for their ability to bind benzodiazepine receptors (BZRs). Most of the synthesized compounds showed micromolar affinity for BZR peripheral type, but not for the central one, with the exception of compound 4m which displayed an IC50=0.407 μM, only 2 fold higher than IC50 for chlordiazepoxide.

Original languageEnglish
Pages (from-to)191-202
Number of pages12
JournalFarmaco
Volume47
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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