Synthesis and binding properties of new endothelin receptor ligands

Maria Modica, Loredana Salerno, Valeria Pittalà, Giuseppe Romeo, Mariangela Siracusa, Ilario Mereghetti, Alfredo Cagnotto, Tiziana Mennini

Research output: Contribution to journal › Article

Abstract

In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ET Ah and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6-trimethylphenyl) benzamide (23) was the most interesting.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalLetters in Drug Design and Discovery
Volume4
Issue number3
DOIs
Publication statusPublished - Apr 2007

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Endothelin Receptors
Ligands
benzenesulfonamide
benzamide

Keywords

  • Benzenesulfonamides
  • Binding properties
  • Endothelins
  • ET receptors
  • G protein-coupled receptors
  • Hypertension

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

Cite this

Modica, M., Salerno, L., Pittalà, V., Romeo, G., Siracusa, M., Mereghetti, I., ... Mennini, T. (2007). Synthesis and binding properties of new endothelin receptor ligands. Letters in Drug Design and Discovery, 4(3), 232-238. https://doi.org/10.2174/157018007780077426

Synthesis and binding properties of new endothelin receptor ligands. / Modica, Maria; Salerno, Loredana; Pittalà, Valeria; Romeo, Giuseppe; Siracusa, Mariangela; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana.

In: Letters in Drug Design and Discovery, Vol. 4, No. 3, 04.2007, p. 232-238.

Research output: Contribution to journal › Article

Modica, M, Salerno, L, Pittalà, V, Romeo, G, Siracusa, M, Mereghetti, I, Cagnotto, A & Mennini, T 2007, 'Synthesis and binding properties of new endothelin receptor ligands', Letters in Drug Design and Discovery, vol. 4, no. 3, pp. 232-238. https://doi.org/10.2174/157018007780077426
Modica M, Salerno L, Pittalà V, Romeo G, Siracusa M, Mereghetti I et al. Synthesis and binding properties of new endothelin receptor ligands. Letters in Drug Design and Discovery. 2007 Apr;4(3):232-238. https://doi.org/10.2174/157018007780077426
Modica, Maria ; Salerno, Loredana ; Pittalà, Valeria ; Romeo, Giuseppe ; Siracusa, Mariangela ; Mereghetti, Ilario ; Cagnotto, Alfredo ; Mennini, Tiziana. / Synthesis and binding properties of new endothelin receptor ligands. In: Letters in Drug Design and Discovery. 2007 ; Vol. 4, No. 3. pp. 232-238.
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