Synthesis and binding properties of new endothelin receptor ligands

Maria Modica, Loredana Salerno, Valeria Pittalà, Giuseppe Romeo, Mariangela Siracusa, Ilario Mereghetti, Alfredo Cagnotto, Tiziana Mennini

Research output: Contribution to journalArticlepeer-review


In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ET Ah and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6-trimethylphenyl) benzamide (23) was the most interesting.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalLetters in Drug Design and Discovery
Issue number3
Publication statusPublished - Apr 2007


  • Benzenesulfonamides
  • Binding properties
  • Endothelins
  • ET receptors
  • G protein-coupled receptors
  • Hypertension

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine


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