Synthesis and biological activity of a conformationally constrained chemotactic γ-lactam formyl tetrapeptide

Giorgio Cavicchioni, Angela Breveglieri, Eva Reali, Susanna Spisani

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The synthesis and biological activity on human neutrophils of for-Met-(γ-lactam)-Leu-Phe-OMe [fM(γl)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.

Original languageEnglish
Pages (from-to)964-966
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume46
Issue number10
Publication statusPublished - 1996

Fingerprint

Lactams
Muramidase
Bioactivity
Human Activities
Superoxides
Neutrophils
chemotactic tetrapeptide
formylmethionyl-leucyl-phenylalanine methyl ester

Keywords

  • chemotaxis
  • human neutrophils
  • lysozyme release
  • N-formylmethionyl peptides
  • superoxide anion generation

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Synthesis and biological activity of a conformationally constrained chemotactic γ-lactam formyl tetrapeptide. / Cavicchioni, Giorgio; Breveglieri, Angela; Reali, Eva; Spisani, Susanna.

In: Arzneimittel-Forschung/Drug Research, Vol. 46, No. 10, 1996, p. 964-966.

Research output: Contribution to journalArticle

Cavicchioni, Giorgio ; Breveglieri, Angela ; Reali, Eva ; Spisani, Susanna. / Synthesis and biological activity of a conformationally constrained chemotactic γ-lactam formyl tetrapeptide. In: Arzneimittel-Forschung/Drug Research. 1996 ; Vol. 46, No. 10. pp. 964-966.
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