Synthesis and biological activity of Akt/PI3K inhibitors

Cristina Redaelli, F. Granucci, L. De Gioia, Laura Cipolla

Research output: Contribution to journalArticle

Abstract

Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interuption and therapeutic applications will be reviewed.

Original languageEnglish
Pages (from-to)1127-1136
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume6
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Akt
  • Allosteric inhibitors
  • Cancer
  • Kinase inhibitors
  • Kinases
  • Phosphatidylinositol
  • Phosphatidylinositol analogues
  • PI3K

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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