Synthesis and biological activity of Akt/PI3K inhibitors

Cristina Redaelli, F. Granucci, L. De Gioia, Laura Cipolla

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interuption and therapeutic applications will be reviewed.

Original languageEnglish
Pages (from-to)1127-1136
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume6
Issue number10
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Protein-Serine-Threonine Kinases
Pathology
Phosphatidylinositols
Bioactivity
Phosphotransferases
Molecules
Neoplasms
Therapeutics

Keywords

  • Akt
  • Allosteric inhibitors
  • Cancer
  • Kinase inhibitors
  • Kinases
  • Phosphatidylinositol
  • Phosphatidylinositol analogues
  • PI3K

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

Cite this

Synthesis and biological activity of Akt/PI3K inhibitors. / Redaelli, Cristina; Granucci, F.; De Gioia, L.; Cipolla, Laura.

In: Mini-Reviews in Medicinal Chemistry, Vol. 6, No. 10, 10.2006, p. 1127-1136.

Research output: Contribution to journalArticle

Redaelli, C, Granucci, F, De Gioia, L & Cipolla, L 2006, 'Synthesis and biological activity of Akt/PI3K inhibitors', Mini-Reviews in Medicinal Chemistry, vol. 6, no. 10, pp. 1127-1136. https://doi.org/10.2174/138955706778560139
Redaelli, Cristina ; Granucci, F. ; De Gioia, L. ; Cipolla, Laura. / Synthesis and biological activity of Akt/PI3K inhibitors. In: Mini-Reviews in Medicinal Chemistry. 2006 ; Vol. 6, No. 10. pp. 1127-1136.
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