Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interuption and therapeutic applications will be reviewed.
- Allosteric inhibitors
- Kinase inhibitors
- Phosphatidylinositol analogues
ASJC Scopus subject areas
- Medicine (miscellaneous)