Synthesis and biological activity of gold and tin compounds in ovarian cancer cells

Monica Cagnoli, Angela Alama, Federica Barbieri, Federica Novelli, Cristina Bruzzo, Fabio Sparatore

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated the patterns of in vitro cytotoxicity, induced by six newly synthesized gold and tin compounds, in three human ovarian cancer cell lines (SW 626, IGROV 1 and OVCAR-3). Four gold compounds, i.e. gold(I)lupinylsulfide hydrochloride [1] (containing a naked gold atom), triethylphosphinogold(I)lupinylsulfide hydrochloride [2], triphenyl-phosphinogold(I)lupinylsulfide hydrochloride [3] and 1,2-bis(diphenylphosphino)ethane bis[gold(I)lupinylsulfide] dihydrochloride [4] (all containing a gold atom coordinated with different phosphines), were prepared. Moreover, the triethylphosphinogold(I)(2-diethylamino)ethylsulfide hydrochloride [5] in which the simple diethylaminoethylthiol replaced the bulky lupinylthiol was synthesized. The tin compound, triethyltin(IV)lupinylsulfide hydrochloride [6], was also studied. Comparative tests with cisplatin, the most widely used antitumor agent in ovarian cancer, were carried out in biological investigations. In vitro cytotoxicity, by MTT assay, showed that compound [4] and compound [6] exhibited interesting antiproliferative activity in all the three cell lines (mean IC50=1.3 and 0.7 μM, respectively) compared to cisplatin (mean IC50=4.8 μM). In addition, the PA-1 cell line, more sensitive to cisplatin (IC50=0.6 μM), was included as a comparison in the study. Cell count assays confirmed the cytotoxin properties of compounds [4] and [6] against the four cell lines, reporting higher growth inhibition potency then cisplatin, with IC50 values in the sub-micromolar range.

Original languageEnglish
Pages (from-to)603-610
Number of pages8
JournalAnti-Cancer Drugs
Volume9
Issue number7
DOIs
Publication statusPublished - 1998

Keywords

  • Antitumor activity
  • Gold
  • Ovarian cancer
  • Tin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

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