Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity

Palmarisa Franchetti, Ghassan Abu Sheikha, Loredana Cappellacci, Mario Grifantini, Emanuela Balestra, Carlo Federico Perno, Giorgio Brandi, Luigia Rossi, Mauro Magnani

Research output: Contribution to journalArticle

Abstract

A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication.

Original languageEnglish
Pages (from-to)989-990
Number of pages2
JournalNucleosides and Nucleotides
Volume18
Issue number4-5
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity'. Together they form a unique fingerprint.

  • Cite this

    Franchetti, P., Sheikha, G. A., Cappellacci, L., Grifantini, M., Balestra, E., Perno, C. F., Brandi, G., Rossi, L., & Magnani, M. (1999). Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity. Nucleosides and Nucleotides, 18(4-5), 989-990.