Synthesis and biological evaluation of novel lipid A antagonists

Francesco Peri, Chiara Marinzi, Marek Barath, Francesca Granucci, Matteo Urbano, Francesco Nicotra

Research output: Contribution to journalArticlepeer-review

Abstract

A mimetic of Lipid A with a β-N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its β-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflammatory activity.

Original languageEnglish
Pages (from-to)190-199
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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