Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Pilar Elías-Rodríguez, Elena Moreno-Clavijo, Sebastián Carrión-Jiménez, Ana T. Carmona, Antonio J. Moreno-Vargas, Irene Caffa, Fabrizio Montecucco, Michele Cea, Alessio Nencioni, Inmaculada Robina

Research output: Contribution to journalArticle

Abstract

A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for their ability to inhibit the growth of pancreatic ductal adenocarcinoma cells in vitro. The new compounds are shown to exhibit anticancer activity at concentrations in the μM range.

Original languageEnglish
Pages (from-to)197-214
Number of pages18
JournalArkivoc
Volume2014
Issue number3
DOIs
Publication statusPublished - Feb 19 2014

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Keywords

  • Amphiphilic compounds
  • Iminoalditols
  • Pancreatic cancer
  • Pyrrolidines

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Elías-Rodríguez, P., Moreno-Clavijo, E., Carrión-Jiménez, S., Carmona, A. T., Moreno-Vargas, A. J., Caffa, I., Montecucco, F., Cea, M., Nencioni, A., & Robina, I. (2014). Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives. Arkivoc, 2014(3), 197-214. https://doi.org/10.3998/ark.5550190.p008.492