Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Pilar Elías-Rodríguez; Elena Moreno-Clavijo; Sebastián Carrión-Jiménez; Ana T. Carmona; Antonio J. Moreno-Vargas; Irene Caffa; Fabrizio Montecucco; Michele Cea; Alessio Nencioni; Inmaculada Robina

doi:10.3998/ark.5550190.p008.492

Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Pilar Elías-Rodríguez, Elena Moreno-Clavijo, Sebastián Carrión-Jiménez, Ana T. Carmona, Antonio J. Moreno-Vargas, Irene Caffa, Fabrizio Montecucco, Michele Cea, Alessio Nencioni, Inmaculada Robina

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article

Abstract

A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for their ability to inhibit the growth of pancreatic ductal adenocarcinoma cells in vitro. The new compounds are shown to exhibit anticancer activity at concentrations in the μM range.

Original language	English
Pages (from-to)	197-214
Number of pages	18
Journal	Arkivoc
Volume	2014
Issue number	3
DOIs	https://doi.org/10.3998/ark.5550190.p008.492
Publication status	Published - Feb 19 2014

Fingerprint

Keywords

Amphiphilic compounds
Iminoalditols
Pancreatic cancer
Pyrrolidines

ASJC Scopus subject areas

Organic Chemistry

Cite this

Elías-Rodríguez, P., Moreno-Clavijo, E., Carrión-Jiménez, S., Carmona, A. T., Moreno-Vargas, A. J., Caffa, I., Montecucco, F., Cea, M., Nencioni, A., & Robina, I. (2014). Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives. Arkivoc, 2014(3), 197-214. https://doi.org/10.3998/ark.5550190.p008.492

Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives. / Elías-Rodríguez, Pilar; Moreno-Clavijo, Elena; Carrión-Jiménez, Sebastián; Carmona, Ana T.; Moreno-Vargas, Antonio J.; Caffa, Irene; Montecucco, Fabrizio; Cea, Michele; Nencioni, Alessio; Robina, Inmaculada.

In: Arkivoc, Vol. 2014, No. 3, 19.02.2014, p. 197-214.

Research output: Contribution to journal › Article

Elías-Rodríguez, Pilar ; Moreno-Clavijo, Elena ; Carrión-Jiménez, Sebastián ; Carmona, Ana T. ; Moreno-Vargas, Antonio J. ; Caffa, Irene ; Montecucco, Fabrizio ; Cea, Michele ; Nencioni, Alessio ; Robina, Inmaculada. / Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives. In: Arkivoc. 2014 ; Vol. 2014, No. 3. pp. 197-214.

@article{6adda5a3c64f43068d885300d389159a,

title = "Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives",

abstract = "A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for their ability to inhibit the growth of pancreatic ductal adenocarcinoma cells in vitro. The new compounds are shown to exhibit anticancer activity at concentrations in the μM range.",

keywords = "Amphiphilic compounds, Iminoalditols, Pancreatic cancer, Pyrrolidines",

author = "Pilar El{\'i}as-Rodr{\'i}guez and Elena Moreno-Clavijo and Sebasti{\'a}n Carri{\'o}n-Jim{\'e}nez and Carmona, {Ana T.} and Moreno-Vargas, {Antonio J.} and Irene Caffa and Fabrizio Montecucco and Michele Cea and Alessio Nencioni and Inmaculada Robina",

year = "2014",

month = feb

day = "19",

doi = "10.3998/ark.5550190.p008.492",

language = "English",

volume = "2014",

pages = "197--214",

journal = "Arkivoc",

issn = "1424-6376",

publisher = "Arkat USA",

number = "3",

}

TY - JOUR

T1 - Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

AU - Elías-Rodríguez, Pilar

AU - Moreno-Clavijo, Elena

AU - Carrión-Jiménez, Sebastián

AU - Carmona, Ana T.

AU - Moreno-Vargas, Antonio J.

AU - Caffa, Irene

AU - Montecucco, Fabrizio

AU - Cea, Michele

AU - Nencioni, Alessio

AU - Robina, Inmaculada

PY - 2014/2/19

Y1 - 2014/2/19

N2 - A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for their ability to inhibit the growth of pancreatic ductal adenocarcinoma cells in vitro. The new compounds are shown to exhibit anticancer activity at concentrations in the μM range.

AB - A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for their ability to inhibit the growth of pancreatic ductal adenocarcinoma cells in vitro. The new compounds are shown to exhibit anticancer activity at concentrations in the μM range.

KW - Amphiphilic compounds

KW - Iminoalditols

KW - Pancreatic cancer

KW - Pyrrolidines

UR - http://www.scopus.com/inward/record.url?scp=84900409775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900409775&partnerID=8YFLogxK

U2 - 10.3998/ark.5550190.p008.492

DO - 10.3998/ark.5550190.p008.492

M3 - Article

AN - SCOPUS:84900409775

VL - 2014

SP - 197

EP - 214

JO - Arkivoc

JF - Arkivoc

SN - 1424-6376

IS - 3

ER -

Access to Document

10.3998/ark.5550190.p008.492