Synthesis and cytotoxic activity of (±) octadecylphosphodithionyl-1-myo-inositol

Maria A. Alisi, Mario Brufani, Luigi Filocamo, Gianluca Gostoli, Luciano Cellai, M. Adeilade Iannelli, Gennaro Melino, Maria C. Cesta, Sperandina Lappa

Research output: Contribution to journalArticle

Abstract

the synthesis of the phosphatidylinositol (PI) analogue (±)-octadecylphosphodithionyl-1-myo-inositol is described. The cytotoxic activity on K562 erythroleukaemic cells and the effect on the activity of PI specific phospholipase C (PI-PLC) from human platelets are reported.

Original languageEnglish
Pages (from-to)1931-1934
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number10
DOIs
Publication statusPublished - 1993

Fingerprint

Phosphoinositide Phospholipase C
K562 Cells
Inositol
Platelets
Phosphatidylinositols
Blood Platelets
Thermodynamic properties
human phosphatidylinositol specific phospholipase C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Alisi, M. A., Brufani, M., Filocamo, L., Gostoli, G., Cellai, L., Iannelli, M. A., ... Lappa, S. (1993). Synthesis and cytotoxic activity of (±) octadecylphosphodithionyl-1-myo-inositol. Bioorganic and Medicinal Chemistry Letters, 3(10), 1931-1934. https://doi.org/10.1016/S0960-894X(01)80989-6

Synthesis and cytotoxic activity of (±) octadecylphosphodithionyl-1-myo-inositol. / Alisi, Maria A.; Brufani, Mario; Filocamo, Luigi; Gostoli, Gianluca; Cellai, Luciano; Iannelli, M. Adeilade; Melino, Gennaro; Cesta, Maria C.; Lappa, Sperandina.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 10, 1993, p. 1931-1934.

Research output: Contribution to journalArticle

Alisi, MA, Brufani, M, Filocamo, L, Gostoli, G, Cellai, L, Iannelli, MA, Melino, G, Cesta, MC & Lappa, S 1993, 'Synthesis and cytotoxic activity of (±) octadecylphosphodithionyl-1-myo-inositol', Bioorganic and Medicinal Chemistry Letters, vol. 3, no. 10, pp. 1931-1934. https://doi.org/10.1016/S0960-894X(01)80989-6
Alisi, Maria A. ; Brufani, Mario ; Filocamo, Luigi ; Gostoli, Gianluca ; Cellai, Luciano ; Iannelli, M. Adeilade ; Melino, Gennaro ; Cesta, Maria C. ; Lappa, Sperandina. / Synthesis and cytotoxic activity of (±) octadecylphosphodithionyl-1-myo-inositol. In: Bioorganic and Medicinal Chemistry Letters. 1993 ; Vol. 3, No. 10. pp. 1931-1934.
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