Synthesis and cytotoxic activity of (±) octadecylphosphodithionyl-1-myo-inositol

Maria A. Alisi, Mario Brufani, Luigi Filocamo, Gianluca Gostoli, Luciano Cellai, M. Adeilade Iannelli, Gennaro Melino, Maria C. Cesta, Sperandina Lappa

Research output: Contribution to journalArticlepeer-review

Abstract

the synthesis of the phosphatidylinositol (PI) analogue (±)-octadecylphosphodithionyl-1-myo-inositol is described. The cytotoxic activity on K562 erythroleukaemic cells and the effect on the activity of PI specific phospholipase C (PI-PLC) from human platelets are reported.

Original languageEnglish
Pages (from-to)1931-1934
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number10
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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