Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

Stefano D'Errico, Giorgia Oliviero, Nicola Borbone, Elena Di Gennaro, Andrea Ilaria Zotti, Alfredo Budillon, Vincenzo Cerullo, Fabrizia Nici, Luciano Mayol, Vincenzo Piccialli, Gennaro Piccialli

Research output: Contribution to journalArticlepeer-review

Abstract

Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.

Original languageEnglish
Pages (from-to)7550-7556
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number34
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Antitumor agents
  • Medicinal chemistry
  • Nucleosides
  • Platinum

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex'. Together they form a unique fingerprint.

Cite this