Abstract
Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.
Original language | English |
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Pages (from-to) | 7550-7556 |
Number of pages | 7 |
Journal | European Journal of Organic Chemistry |
Volume | 2015 |
Issue number | 34 |
DOIs | |
Publication status | Published - Dec 1 2015 |
Keywords
- Antitumor agents
- Medicinal chemistry
- Nucleosides
- Platinum
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry