Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

Stefano D'Errico; Giorgia Oliviero; Nicola Borbone; Elena Di Gennaro; Andrea Ilaria Zotti; Alfredo Budillon; Vincenzo Cerullo; Fabrizia Nici; Luciano Mayol; Vincenzo Piccialli; Gennaro Piccialli

doi:10.1002/ejoc.201500998

Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

Stefano D'Errico, Giorgia Oliviero, Nicola Borbone, Elena Di Gennaro, Andrea Ilaria Zotti, Alfredo Budillon, Vincenzo Cerullo, Fabrizia Nici, Luciano Mayol, Vincenzo Piccialli, Gennaro Piccialli

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.

Original language	English
Pages (from-to)	7550-7556
Number of pages	7
Journal	European Journal of Organic Chemistry
Volume	2015
Issue number	34
DOIs	https://doi.org/10.1002/ejoc.201500998
Publication status	Published - Dec 1 2015

Keywords

Antitumor agents
Medicinal chemistry
Nucleosides
Platinum

ASJC Scopus subject areas

Organic Chemistry
Physical and Theoretical Chemistry

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10.1002/ejoc.201500998

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Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex. / D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Di Gennaro, Elena; Zotti, Andrea Ilaria; Budillon, Alfredo; Cerullo, Vincenzo; Nici, Fabrizia; Mayol, Luciano; Piccialli, Vincenzo; Piccialli, Gennaro.

In: European Journal of Organic Chemistry, Vol. 2015, No. 34, 01.12.2015, p. 7550-7556.

Research output: Contribution to journal › Article › peer-review

D'Errico, Stefano ; Oliviero, Giorgia ; Borbone, Nicola ; Di Gennaro, Elena ; Zotti, Andrea Ilaria ; Budillon, Alfredo ; Cerullo, Vincenzo ; Nici, Fabrizia ; Mayol, Luciano ; Piccialli, Vincenzo ; Piccialli, Gennaro. / Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex. In: European Journal of Organic Chemistry. 2015 ; Vol. 2015, No. 34. pp. 7550-7556.

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abstract = "Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.",

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AU - Di Gennaro, Elena

AU - Zotti, Andrea Ilaria

AU - Budillon, Alfredo

AU - Cerullo, Vincenzo

AU - Nici, Fabrizia

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AU - Piccialli, Vincenzo

AU - Piccialli, Gennaro

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Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

Abstract

Keywords

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