Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold

Stefano D'Errico; Nicola Borbone; Vincenzo Piccialli; Elena Di Gennaro; Andrea Zotti; Alfredo Budillon; Carlo Vitagliano; Ilaria Piccialli; Giorgia Oliviero

doi:10.1002/ejoc.201700730

Synthesis and Evaluation of the Antitumor Properties of a Small Collection of Pt^II Complexes with 7-Deazaadenosine as Scaffold

Stefano D'Errico, Nicola Borbone, Vincenzo Piccialli, Elena Di Gennaro, Andrea Zotti, Alfredo Budillon, Carlo Vitagliano, Ilaria Piccialli, Giorgia Oliviero

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Herein we report on the synthesis and evaluation of the preliminary antitumor properties of a small collection of platinum(II) complexes in which a cisplatin-like unit is tethered to 7-deazaadenosine through linear alkyl chains (from two to six carbon atoms) installed at the purine C6 position. The complexation was performed by exploiting the reactivity of the bidentate amino ligands (R)- and (S)-2,3-diaminopropanoic acids (DAPA) attached to the end of the alkyl chain spacer. By varying the length of the alkyl chain and the chirality of the DAPA moiety we obtained 10 novel nucleoside–platinum complexes, the anticancer properties of which have been evaluated against the A549 and Cal27 human cancer cell lines.

Original language	English
Pages (from-to)	4935-4947
Number of pages	13
Journal	European Journal of Organic Chemistry
Volume	2017
Issue number	33
DOIs	https://doi.org/10.1002/ejoc.201700730
Publication status	Published - Sep 8 2017

Keywords

Antiproliferative activity
Antitumor agents
Nucleosides
Platinum

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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Synthesis and Evaluation of the Antitumor Properties of a Small Collection of Pt^II Complexes with 7-Deazaadenosine as Scaffold. / D'Errico, Stefano; Borbone, Nicola; Piccialli, Vincenzo; Di Gennaro, Elena; Zotti, Andrea; Budillon, Alfredo ; Vitagliano, Carlo; Piccialli, Ilaria; Oliviero, Giorgia.

In: European Journal of Organic Chemistry, Vol. 2017, No. 33, 08.09.2017, p. 4935-4947.

Research output: Contribution to journal › Article › peer-review

D'Errico, Stefano ; Borbone, Nicola ; Piccialli, Vincenzo ; Di Gennaro, Elena ; Zotti, Andrea ; Budillon, Alfredo ; Vitagliano, Carlo ; Piccialli, Ilaria ; Oliviero, Giorgia. / Synthesis and Evaluation of the Antitumor Properties of a Small Collection of Pt^II Complexes with 7-Deazaadenosine as Scaffold. In: European Journal of Organic Chemistry. 2017 ; Vol. 2017, No. 33. pp. 4935-4947.

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