Synthesis and in vitro anti-proliferative activity of racemic trifluoro-Casodex® (Bicalutamide)

Monica Sani; Fiorenza Viani; Mara Binda; Nadia Zaffaroni; Matteo Zanda

doi:10.2174/1570178054405850

Synthesis and in vitro anti-proliferative activity of racemic trifluoro-Casodex® (Bicalutamide)

Monica Sani, Fiorenza Viani, Mara Binda, Nadia Zaffaroni, Matteo Zanda

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro anti-proliferative activity on the human prostate cancer cell line LNCaP.

Original language	English
Pages (from-to)	447-449
Number of pages	3
Journal	Letters in Organic Chemistry
Volume	2
Issue number	5
DOIs	https://doi.org/10.2174/1570178054405850
Publication status	Published - Aug 2005

Keywords

Anti-androgen
Chromatography
Nucleophilic reagents
Prostate cancer
Trifluoro-casodex analogue

ASJC Scopus subject areas

Organic Chemistry
Biochemistry

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abstract = "The trifluoro analogue 1 of Casodex{\textregistered} was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro anti-proliferative activity on the human prostate cancer cell line LNCaP.",

keywords = "Anti-androgen, Chromatography, Nucleophilic reagents, Prostate cancer, Trifluoro-casodex analogue",

author = "Monica Sani and Fiorenza Viani and Mara Binda and Nadia Zaffaroni and Matteo Zanda",

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AU - Viani, Fiorenza

AU - Binda, Mara

AU - Zaffaroni, Nadia

AU - Zanda, Matteo

PY - 2005/8

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KW - Chromatography

KW - Nucleophilic reagents

KW - Prostate cancer

KW - Trifluoro-casodex analogue

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