Abstract
The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro anti-proliferative activity on the human prostate cancer cell line LNCaP.
Original language | English |
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Pages (from-to) | 447-449 |
Number of pages | 3 |
Journal | Letters in Organic Chemistry |
Volume | 2 |
Issue number | 5 |
DOIs | |
Publication status | Published - Aug 2005 |
Keywords
- Anti-androgen
- Chromatography
- Nucleophilic reagents
- Prostate cancer
- Trifluoro-casodex analogue
ASJC Scopus subject areas
- Organic Chemistry
- Biochemistry