Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures

Rosaria Ottanà; Rosanna Maccari; Rosella Ciurleo; Maria Gabriella Vigorita; Anna Maria Panico; Venera Cardile; Floriana Garufi; Simone Ronsisvalle

doi:10.1016/j.bmc.2007.09.001

Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures

Rosaria Ottanà, Rosanna Maccari, Rosella Ciurleo, Maria Gabriella Vigorita, Anna Maria Panico, Venera Cardile, Floriana Garufi, Simone Ronsisvalle

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article

Abstract

5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE₂ and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1β.

Original language	English
Pages (from-to)	7618-7625
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	15
Issue number	24
DOIs	https://doi.org/10.1016/j.bmc.2007.09.001
Publication status	Published - Dec 15 2007

Keywords

2-Phenylimino-4-thiazolidinones
Antidegenerative activity
Human chondrocyte
Osteoarthritis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/j.bmc.2007.09.001

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Ottanà, R., Maccari, R., Ciurleo, R., Vigorita, M. G., Panico, A. M., Cardile, V., Garufi, F., & Ronsisvalle, S. (2007). Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures. Bioorganic and Medicinal Chemistry, 15(24), 7618-7625. https://doi.org/10.1016/j.bmc.2007.09.001

Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures. / Ottanà, Rosaria; Maccari, Rosanna; Ciurleo, Rosella; Vigorita, Maria Gabriella; Panico, Anna Maria; Cardile, Venera; Garufi, Floriana; Ronsisvalle, Simone.

In: Bioorganic and Medicinal Chemistry, Vol. 15, No. 24, 15.12.2007, p. 7618-7625.

Research output: Contribution to journal › Article

Ottanà, R, Maccari, R, Ciurleo, R, Vigorita, MG, Panico, AM, Cardile, V, Garufi, F & Ronsisvalle, S 2007, 'Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures', Bioorganic and Medicinal Chemistry, vol. 15, no. 24, pp. 7618-7625. https://doi.org/10.1016/j.bmc.2007.09.001

Ottanà, Rosaria ; Maccari, Rosanna ; Ciurleo, Rosella ; Vigorita, Maria Gabriella ; Panico, Anna Maria ; Cardile, Venera ; Garufi, Floriana ; Ronsisvalle, Simone. / Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures. In: Bioorganic and Medicinal Chemistry. 2007 ; Vol. 15, No. 24. pp. 7618-7625.

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