Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures

Rosaria Ottanà, Rosanna Maccari, Rosella Ciurleo, Maria Gabriella Vigorita, Anna Maria Panico, Venera Cardile, Floriana Garufi, Simone Ronsisvalle

Research output: Contribution to journalArticle

Abstract

5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE2 and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1β.

Original languageEnglish
Pages (from-to)7618-7625
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume15
Issue number24
DOIs
Publication statusPublished - Dec 15 2007

Keywords

  • 2-Phenylimino-4-thiazolidinones
  • Antidegenerative activity
  • Human chondrocyte
  • Osteoarthritis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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