Abstract
5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE2 and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1β.
| Original language | English |
|---|---|
| Pages (from-to) | 7618-7625 |
| Number of pages | 8 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 15 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Dec 15 2007 |
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Keywords
- 2-Phenylimino-4-thiazolidinones
- Antidegenerative activity
- Human chondrocyte
- Osteoarthritis
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures. / Ottanà, Rosaria; Maccari, Rosanna; Ciurleo, Rosella; Vigorita, Maria Gabriella; Panico, Anna Maria; Cardile, Venera; Garufi, Floriana; Ronsisvalle, Simone.
In: Bioorganic and Medicinal Chemistry, Vol. 15, No. 24, 15.12.2007, p. 7618-7625.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures
AU - Ottanà, Rosaria
AU - Maccari, Rosanna
AU - Ciurleo, Rosella
AU - Vigorita, Maria Gabriella
AU - Panico, Anna Maria
AU - Cardile, Venera
AU - Garufi, Floriana
AU - Ronsisvalle, Simone
PY - 2007/12/15
Y1 - 2007/12/15
N2 - 5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE2 and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1β.
AB - 5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE2 and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1β.
KW - 2-Phenylimino-4-thiazolidinones
KW - Antidegenerative activity
KW - Human chondrocyte
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=35348815102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35348815102&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2007.09.001
DO - 10.1016/j.bmc.2007.09.001
M3 - Article
VL - 15
SP - 7618
EP - 7625
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 24
ER -