TY - JOUR
T1 - Synthesis and pharmacokinetic behaviour of ester derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen) with end-hydroxylated poly(N-vinyl pyrrolidinone) and poly(N-acryloyl morpholine) oligomers
AU - Sartore, Luciana
AU - Peroni, Isabella
AU - Ferruti, Paolo
AU - Latini, Roberto
AU - Bernasconi, Roberto
PY - 1997
Y1 - 1997
N2 - Four derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen), in which the drug was bound by ester linkages to poly(ethylene glycols) (PEG 2000-I), monomethoxy poly(ethylene glycols) (PEG 1900-I), poly(N-vinyl pyrrolidinone) (PVP-I) and poly(N-acryloyl morpholine) (PACM-I), all having approximatively the same number average molecular weight (M̄(n) ~ 2000), were prepared and tested for their pharmacokinetic properties after oral administration. It was found that the two end-hydroxylated amphiphilic oligomers of polyvinylic structure, PACM and PVP, whose physico-chemical properties are comparable to those of PEGs especially as regards solvent affinity, have in principle a similar potential as promoieties for preparing oligomeric prodrugs.
AB - Four derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen), in which the drug was bound by ester linkages to poly(ethylene glycols) (PEG 2000-I), monomethoxy poly(ethylene glycols) (PEG 1900-I), poly(N-vinyl pyrrolidinone) (PVP-I) and poly(N-acryloyl morpholine) (PACM-I), all having approximatively the same number average molecular weight (M̄(n) ~ 2000), were prepared and tested for their pharmacokinetic properties after oral administration. It was found that the two end-hydroxylated amphiphilic oligomers of polyvinylic structure, PACM and PVP, whose physico-chemical properties are comparable to those of PEGs especially as regards solvent affinity, have in principle a similar potential as promoieties for preparing oligomeric prodrugs.
KW - 4-isobutylphenyl-2-propionic acid
KW - Ibuprofen pharmacokinetics oligomeric prodrugs
KW - Oligomeric
KW - Oligomeric poly(n-acryloyl morpholine)
KW - Poly(N-vinyl pyrrolidinone)
UR - http://www.scopus.com/inward/record.url?scp=0030694854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030694854&partnerID=8YFLogxK
M3 - Article
C2 - 9297600
AN - SCOPUS:0030694854
VL - 8
SP - 741
EP - 754
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
SN - 0920-5063
IS - 10
ER -