Synthesis and pharmacokinetic behaviour of ester derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen) with end-hydroxylated poly(N-vinyl pyrrolidinone) and poly(N-acryloyl morpholine) oligomers

Luciana Sartore, Isabella Peroni, Paolo Ferruti, Roberto Latini, Roberto Bernasconi

Research output: Contribution to journalArticle

Abstract

Four derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen), in which the drug was bound by ester linkages to poly(ethylene glycols) (PEG 2000-I), monomethoxy poly(ethylene glycols) (PEG 1900-I), poly(N-vinyl pyrrolidinone) (PVP-I) and poly(N-acryloyl morpholine) (PACM-I), all having approximatively the same number average molecular weight (M̄(n) ~ 2000), were prepared and tested for their pharmacokinetic properties after oral administration. It was found that the two end-hydroxylated amphiphilic oligomers of polyvinylic structure, PACM and PVP, whose physico-chemical properties are comparable to those of PEGs especially as regards solvent affinity, have in principle a similar potential as promoieties for preparing oligomeric prodrugs.

Original languageEnglish
Pages (from-to)741-754
Number of pages14
JournalJournal of Biomaterials Science, Polymer Edition
Volume8
Issue number10
Publication statusPublished - 1997

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Keywords

  • 4-isobutylphenyl-2-propionic acid
  • Ibuprofen pharmacokinetics oligomeric prodrugs
  • Oligomeric
  • Oligomeric poly(n-acryloyl morpholine)
  • Poly(N-vinyl pyrrolidinone)

ASJC Scopus subject areas

  • Biophysics

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