Synthesis and pharmacological evaluation of a new class of 2-oxo-8- azaspiro (4,5)decan-1-ones as analogues of the muscarinic agonist RS-86

G. Cignarella, S. Villa, D. Barlocco

Research output: Contribution to journalArticlepeer-review

Abstract

A new series of 8-substituted-2-oxo-8-azapsiro (4,5)decan-1-ones has been synthesized and compounds tested for their cholinergic properties in comparison with the muscarinic agonist RS-86. Preliminary in vitro and in vivo pharmacological data indicate that none of them is provided with significant cholinergic effects either at central or peripheral level. A possible explanation for the lack of activity is given on the basis of conformational studies.

Original languageEnglish
Pages (from-to)1439-1445
Number of pages7
JournalFarmaco
Volume48
Issue number10
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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