Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor

A. Chiari, D. Fancelli, P. P. Lovisolo, A. Radice, L. Savoia, D. Severino, G. Ghiselli

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis and the pharmacological evaluation of FCE 28654, a novel water-soluble ACAT inhibitor, are reported. The compound positively modifies blood and hepatic cholesterol levels when orally or intravenously administered to hypercholesterolemic animals.

Original languageEnglish
Pages (from-to)1581-1586
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number15
DOIs
Publication statusPublished - Aug 3 1995

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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