Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor

A. Chiari, D. Fancelli, P. P. Lovisolo, A. Radice, L. Savoia, D. Severino, G. Ghiselli

Research output: Contribution to journalArticle

Abstract

The synthesis and the pharmacological evaluation of FCE 28654, a novel water-soluble ACAT inhibitor, are reported. The compound positively modifies blood and hepatic cholesterol levels when orally or intravenously administered to hypercholesterolemic animals.

Original languageEnglish
Pages (from-to)1581-1586
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number15
DOIs
Publication statusPublished - Aug 3 1995

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Animals
Blood
Cholesterol
Pharmacology
Injections
Water
Liver

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Chiari, A., Fancelli, D., Lovisolo, P. P., Radice, A., Savoia, L., Severino, D., & Ghiselli, G. (1995). Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic and Medicinal Chemistry Letters, 5(15), 1581-1586. https://doi.org/10.1016/0960-894X(95)00275-X

Synthesis and pharmacological profile of FCE 28654 : A water-soluble and injectable ACAT inhibitor. / Chiari, A.; Fancelli, D.; Lovisolo, P. P.; Radice, A.; Savoia, L.; Severino, D.; Ghiselli, G.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 5, No. 15, 03.08.1995, p. 1581-1586.

Research output: Contribution to journalArticle

Chiari, A, Fancelli, D, Lovisolo, PP, Radice, A, Savoia, L, Severino, D & Ghiselli, G 1995, 'Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor', Bioorganic and Medicinal Chemistry Letters, vol. 5, no. 15, pp. 1581-1586. https://doi.org/10.1016/0960-894X(95)00275-X
Chiari, A. ; Fancelli, D. ; Lovisolo, P. P. ; Radice, A. ; Savoia, L. ; Severino, D. ; Ghiselli, G. / Synthesis and pharmacological profile of FCE 28654 : A water-soluble and injectable ACAT inhibitor. In: Bioorganic and Medicinal Chemistry Letters. 1995 ; Vol. 5, No. 15. pp. 1581-1586.
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