Synthesis and receptor binding studies of 2-functionalized 1,4-benzodiazepine derivatives as potential metaclazepam-like antianxiety agents

M. Anzini, A. Cappelli, S. Vomero, A. Cagnotto, M. Skorupska

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of 7-chloro-2,3-dihydro-2-(2-methoxyethyl)-1-methyl-5-phenyl-1H-1,4-benzo diazepine (2) is described. While the metaclazepam-like compound 2 showed an affinity for benzodiazepine receptor central type (CBZRs) comparable to that of metaclazepam (1a), its intermediates bearing the exocyclic double bond resulted more active.

Original languageEnglish
Pages (from-to)897-905
Number of pages9
JournalFarmaco
Volume48
Issue number7
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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