The synthesis of 7-chloro-2,3-dihydro-2-(2-methoxyethyl)-1-methyl-5-phenyl-1H-1,4-benzo diazepine (2) is described. While the metaclazepam-like compound 2 showed an affinity for benzodiazepine receptor central type (CBZRs) comparable to that of metaclazepam (1a), its intermediates bearing the exocyclic double bond resulted more active.
|Number of pages||9|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Drug Discovery
- Pharmaceutical Science