Synthesis and structural characterisation as 12-helix of the hexamer of a β-amino acid tethered to a pyrrolidin-2-one ring

Ileana Menegazzo, Alexander Fries, Stefano Mammi, Roberta Galeazzi, Gianluca Martelli, Mario Orena, Samuele Rinaldi

Research output: Contribution to journalArticle

Abstract

Starting from (3S,4R,1′S)-3-amino-2-oxo-1-[1′-(4- methoxyphenylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a β-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirmed by molecular dynamics (MD) simulations.

Original languageEnglish
Pages (from-to)4915-4917
Number of pages3
JournalChemical Communications
Issue number47
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Chemistry(all)

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