Synthesis by pulsed laser ablation of 2D nanostructures for advanced biomedical sensing

S. Trusso, C. Zanchi, A. Bombelli, A. Lucotti, M. Tommasini, U. De Grazia, E. Ciusani, L. M. Romito, P. M. Ossi

Research output: Contribution to journalArticlepeer-review


Au nanoparticle arrays with controlled nanostructure were produced by pulsed laser ablation on glass. Such substrates were optimized for biomedical sensing by means of SERS keeping fixed all process parameters but the laser pulse (LP) number that is a key deposition parameter. It allows to fine-tune the Au surface nanostructure with a considerable improvement in the SERS response towards the detection of apomorphine in blood serum (3.3 × 10-6 M), when LP number is increased from 1 × 104 to 2 × 104. This result is the starting point to correlate the intensity of selected SERS signals of apomorphine to its concentration in the blood of patients with Parkinson's disease.

Original languageEnglish
Article numberC05006
JournalJournal of Instrumentation
Issue number5
Publication statusPublished - May 6 2016


  • Detection of contraband and drugs
  • Interaction of radiation with matter
  • Materials for solid-state detectors
  • Plasma generation (laser-produced, RF, x ray-produced)

ASJC Scopus subject areas

  • Instrumentation
  • Mathematical Physics


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