Synthesis by pulsed laser ablation of 2D nanostructures for advanced biomedical sensing

S. Trusso; C. Zanchi; A. Bombelli; A. Lucotti; M. Tommasini; U. De Grazia; E. Ciusani; L. M. Romito; P. M. Ossi

doi:10.1088/1748-0221/11/05/C05006

Synthesis by pulsed laser ablation of 2D nanostructures for advanced biomedical sensing

S. Trusso, C. Zanchi, A. Bombelli, A. Lucotti, M. Tommasini, U. De Grazia, E. Ciusani, L. M. Romito, P. M. Ossi

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Au nanoparticle arrays with controlled nanostructure were produced by pulsed laser ablation on glass. Such substrates were optimized for biomedical sensing by means of SERS keeping fixed all process parameters but the laser pulse (LP) number that is a key deposition parameter. It allows to fine-tune the Au surface nanostructure with a considerable improvement in the SERS response towards the detection of apomorphine in blood serum (3.3 × 10^-6 M), when LP number is increased from 1 × 10⁴ to 2 × 10⁴. This result is the starting point to correlate the intensity of selected SERS signals of apomorphine to its concentration in the blood of patients with Parkinson's disease.

Original language	English
Article number	C05006
Journal	Journal of Instrumentation
Volume	11
Issue number	5
DOIs	https://doi.org/10.1088/1748-0221/11/05/C05006
Publication status	Published - May 6 2016

Keywords

Detection of contraband and drugs
Interaction of radiation with matter
Materials for solid-state detectors
Plasma generation (laser-produced, RF, x ray-produced)

ASJC Scopus subject areas

Instrumentation
Mathematical Physics

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abstract = "Au nanoparticle arrays with controlled nanostructure were produced by pulsed laser ablation on glass. Such substrates were optimized for biomedical sensing by means of SERS keeping fixed all process parameters but the laser pulse (LP) number that is a key deposition parameter. It allows to fine-tune the Au surface nanostructure with a considerable improvement in the SERS response towards the detection of apomorphine in blood serum (3.3 × 10-6 M), when LP number is increased from 1 × 104 to 2 × 104. This result is the starting point to correlate the intensity of selected SERS signals of apomorphine to its concentration in the blood of patients with Parkinson's disease.",

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AU - Trusso, S.

AU - Zanchi, C.

AU - Bombelli, A.

AU - Lucotti, A.

AU - Tommasini, M.

AU - De Grazia, U.

AU - Ciusani, E.

AU - Romito, L. M.

AU - Ossi, P. M.

PY - 2016/5/6

Y1 - 2016/5/6

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KW - Detection of contraband and drugs

KW - Interaction of radiation with matter

KW - Materials for solid-state detectors

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Synthesis by pulsed laser ablation of 2D nanostructures for advanced biomedical sensing

Abstract

Keywords

ASJC Scopus subject areas

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