Synthesis, characterization and anticancer activity of gold(III) complexes with (1R,2R)-(-)-1,2-diaminocyclohexane

Khalid H. Omer, Adam A. Seliman, Muhammad Altaf, Naike Casagrande, Donatella Aldinucci, Saleh Altuwaijri, Anvarhusein A. Isab

Research output: Contribution to journalArticlepeer-review

Abstract

Two gold(III) complexes, [(DACH)AuCl2]Cl (1) and [(DACH)2Au]Cl3 (2), derived from (1R,2R)-(-)-1,2-diaminocyclohexane and sodium tetrachloroaurate dihydrate, NaAuCl4·2H2O, were synthesized and fully characterized using elemental analysis and different physical methods, such as FTIR, 1H NMR, 13C NMR, solid-state NMR and X-ray crystallography. The data confirm the coordination of the DACH ligand to the gold(III) metal centre through its nitrogen atoms. According to in vitro cytotoxic studies, complex 2 was more effective against the three human tumor cell lines evaluated (the ovarian cancer cell line A2780, its cisplatin-resistant clone A2780cis and the classical Hodgkin lymphoma cell line L-540). The fold-resistance of the A2780 and A2780cis cells to cisplatin was about twofold lower for both gold(III) complexes.

Original languageEnglish
Pages (from-to)773-781
Number of pages9
JournalPolyhedron
Volume102
DOIs
Publication statusPublished - Dec 14 2015

Keywords

  • (1R,2R)-(-)-1,2-diaminocyclohexane
  • Cancer cell line
  • Gold(III) complexes
  • L-540
  • X-ray crystallography

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Materials Chemistry
  • Physical and Theoretical Chemistry

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