TY - JOUR
T1 - Synthesis, characterization and anticancer activity of gold(III) complexes with (1R,2R)-(-)-1,2-diaminocyclohexane
AU - Omer, Khalid H.
AU - Seliman, Adam A.
AU - Altaf, Muhammad
AU - Casagrande, Naike
AU - Aldinucci, Donatella
AU - Altuwaijri, Saleh
AU - Isab, Anvarhusein A.
PY - 2015/12/14
Y1 - 2015/12/14
N2 - Two gold(III) complexes, [(DACH)AuCl2]Cl (1) and [(DACH)2Au]Cl3 (2), derived from (1R,2R)-(-)-1,2-diaminocyclohexane and sodium tetrachloroaurate dihydrate, NaAuCl4·2H2O, were synthesized and fully characterized using elemental analysis and different physical methods, such as FTIR, 1H NMR, 13C NMR, solid-state NMR and X-ray crystallography. The data confirm the coordination of the DACH ligand to the gold(III) metal centre through its nitrogen atoms. According to in vitro cytotoxic studies, complex 2 was more effective against the three human tumor cell lines evaluated (the ovarian cancer cell line A2780, its cisplatin-resistant clone A2780cis and the classical Hodgkin lymphoma cell line L-540). The fold-resistance of the A2780 and A2780cis cells to cisplatin was about twofold lower for both gold(III) complexes.
AB - Two gold(III) complexes, [(DACH)AuCl2]Cl (1) and [(DACH)2Au]Cl3 (2), derived from (1R,2R)-(-)-1,2-diaminocyclohexane and sodium tetrachloroaurate dihydrate, NaAuCl4·2H2O, were synthesized and fully characterized using elemental analysis and different physical methods, such as FTIR, 1H NMR, 13C NMR, solid-state NMR and X-ray crystallography. The data confirm the coordination of the DACH ligand to the gold(III) metal centre through its nitrogen atoms. According to in vitro cytotoxic studies, complex 2 was more effective against the three human tumor cell lines evaluated (the ovarian cancer cell line A2780, its cisplatin-resistant clone A2780cis and the classical Hodgkin lymphoma cell line L-540). The fold-resistance of the A2780 and A2780cis cells to cisplatin was about twofold lower for both gold(III) complexes.
KW - (1R,2R)-(-)-1,2-diaminocyclohexane
KW - Cancer cell line
KW - Gold(III) complexes
KW - L-540
KW - X-ray crystallography
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U2 - 10.1016/j.poly.2015.10.029
DO - 10.1016/j.poly.2015.10.029
M3 - Article
AN - SCOPUS:84949547270
VL - 102
SP - 773
EP - 781
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
ER -