Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids

Olga Bortolini, Giancarlo Fantin, Marco Fogagnolo, Stefano Rossetti, Loredana Maiuolo, Gemma Di Pompo, Sofia Avnet, Donatella Granchi

Research output: Contribution to journalArticle

Abstract

Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume52
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Bile acids
  • Biological activity
  • Hydroxy-bisphosphonates
  • Hydroxyapatite affinity

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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