Synthesis, cytotoxic effect and antiviral activity of 1-(β-D- arabinofuranosyl)-5-bromo-N4-substituted cytosine and 1-(β-D- arabinofuranosyl)-5-bromo-4-methoxypyrimidin-2(1H)-one derivatives

Raffaele Saladino, Maurizio Mezzetti, Enrico Mincione, Anna Teresa Palamara, Patrizia Savini, Stefano Marini

Research output: Contribution to journalArticlepeer-review

Abstract

A convenient and mild synthesis of 5-bromo-N4-substituted-1-(β-D- arabinofuranosyl)cytosine and 5-bromo-O4-methyl-1-(β-D- arabinofuranosyl)pyrimidin-2(1H)-one derivatives by selective oxyfunctionalization of the corresponding 4-thionucleosides with 3,3- dimethyldioxirane is reported. The cytotoxicity and the antiviral activity against parainfluenza 1 (Sendai virus) of all new synthesized products are also reported.

Original languageEnglish
Pages (from-to)2499-2510
Number of pages12
JournalNucleosides and Nucleotides
Volume18
Issue number11-12
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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