Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties

M. Marinozzi, B. Natalini, G. Costantino, R. Pellicciari, V. Bruno, F. Nicoletti

Research output: Contribution to journalArticlepeer-review

Abstract

6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalFarmaco
Volume51
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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