Abstract
Cytosine arabinoside (ara-C) is being employed at low dosage as differentiative rather than a cytotoxic agent in the therapy of leukemias. We have analyzed nuclear proteins from HL 60 leukemic cells treated with ara-C and have observed increased expression of a 60 kD protein in dose-dependent fashion. This protein is actively synthesized, as assessed by labeled methionine incorporation. Using DNA cellulose affinity chromatography we could also demonstrate DNA binding properties of the 60 kD protein.
Original language | English |
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Pages (from-to) | 150-153 |
Number of pages | 4 |
Journal | European Journal of Haematology |
Volume | 44 |
Issue number | 3 |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Hematology