Abstract
Cytosine arabinoside (ara-C) is being employed at low dosage as differentiative rather than a cytotoxic agent in the therapy of leukemias. We have analyzed nuclear proteins from HL 60 leukemic cells treated with ara-C and have observed increased expression of a 60 kD protein in dose-dependent fashion. This protein is actively synthesized, as assessed by labeled methionine incorporation. Using DNA cellulose affinity chromatography we could also demonstrate DNA binding properties of the 60 kD protein.
| Original language | English |
|---|---|
| Pages (from-to) | 150-153 |
| Number of pages | 4 |
| Journal | European Journal of Haematology |
| Volume | 44 |
| Issue number | 3 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Hematology
Cite this
Ravazzolo, R., Bianchi-Scarra, G., Capra, V., Fiorentini, P., & Garre, C. (1990). Synthesis of a 60 kD nuclear DNA binding protein induced by cytosine arabinoside in the HL 60 leukemic cell line. European Journal of Haematology, 44(3), 150-153.