Synthesis of a new series of 2,7-diazaspiro[3.5]nonan-1-ones and study of their cholinergic properties

G. Cignarella; S. Villa; D. Barlocco

doi:10.1016/0223-5234(94)90207-0

Synthesis of a new series of 2,7-diazaspiro[3.5]nonan-1-ones and study of their cholinergic properties

G. Cignarella, S. Villa, D. Barlocco

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

A new series of substituted 2,7-diazaspiro[3.5]nonan-1-ones (1a-I), structurally related to the muscarinic agonist RS-86, has been synthesized and tested for cholinergic properties both in vitro and in vivo. None of the compounds showed significant cholinergic properties at either the central or peripheral level. A possible explanation for the lack of activity is given.

Original language	English
Pages (from-to)	115-120
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/0223-5234(94)90207-0
Publication status	Published - 1994

Keywords

Alzheimer's disease
cholinergic system
muscarinic agonists
RS-86

ASJC Scopus subject areas

Molecular Medicine
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/0223-5234(94)90207-0

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AB - A new series of substituted 2,7-diazaspiro[3.5]nonan-1-ones (1a-I), structurally related to the muscarinic agonist RS-86, has been synthesized and tested for cholinergic properties both in vitro and in vivo. None of the compounds showed significant cholinergic properties at either the central or peripheral level. A possible explanation for the lack of activity is given.

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Synthesis of a new series of 2,7-diazaspiro[3.5]nonan-1-ones and study of their cholinergic properties

Abstract

Keywords

ASJC Scopus subject areas

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