Abstract
A new series of substituted 2,7-diazaspiro[3.5]nonan-1-ones (1a-I), structurally related to the muscarinic agonist RS-86, has been synthesized and tested for cholinergic properties both in vitro and in vivo. None of the compounds showed significant cholinergic properties at either the central or peripheral level. A possible explanation for the lack of activity is given.
Original language | English |
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Pages (from-to) | 115-120 |
Number of pages | 6 |
Journal | European Journal of Medicinal Chemistry |
Volume | 29 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1994 |
Keywords
- Alzheimer's disease
- cholinergic system
- muscarinic agonists
- RS-86
ASJC Scopus subject areas
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science