Synthesis of a new series of 2,7-diazaspiro[3.5]nonan-1-ones and study of their cholinergic properties

G. Cignarella, S. Villa, D. Barlocco

Research output: Contribution to journalArticlepeer-review

Abstract

A new series of substituted 2,7-diazaspiro[3.5]nonan-1-ones (1a-I), structurally related to the muscarinic agonist RS-86, has been synthesized and tested for cholinergic properties both in vitro and in vivo. None of the compounds showed significant cholinergic properties at either the central or peripheral level. A possible explanation for the lack of activity is given.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume29
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • Alzheimer's disease
  • cholinergic system
  • muscarinic agonists
  • RS-86

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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