Abstract
A new series of 8-substituted-2,8-diazaspiro[4.5]decan-3-ones has been synthesized and tested in in vitro and in vivo assays predictive for cholinergic activity, in comparison with the muscarinic agent RS-86. Preliminary pharmacological data indicate that the compounds are devoid of significant cholinergic properties.
| Original language | English |
|---|---|
| Pages (from-to) | 1357-1359 |
| Number of pages | 3 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 30 |
| Issue number | 5 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Organic Chemistry
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Synthesis of a new series of 8-substituted-2,8-diazaspiro[4.5]decan-3- ones. / Cignarella, G.; Villa, S.; Barlocco, D.
In: Journal of Heterocyclic Chemistry, Vol. 30, No. 5, 1993, p. 1357-1359.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of a new series of 8-substituted-2,8-diazaspiro[4.5]decan-3- ones
AU - Cignarella, G.
AU - Villa, S.
AU - Barlocco, D.
PY - 1993
Y1 - 1993
N2 - A new series of 8-substituted-2,8-diazaspiro[4.5]decan-3-ones has been synthesized and tested in in vitro and in vivo assays predictive for cholinergic activity, in comparison with the muscarinic agent RS-86. Preliminary pharmacological data indicate that the compounds are devoid of significant cholinergic properties.
AB - A new series of 8-substituted-2,8-diazaspiro[4.5]decan-3-ones has been synthesized and tested in in vitro and in vivo assays predictive for cholinergic activity, in comparison with the muscarinic agent RS-86. Preliminary pharmacological data indicate that the compounds are devoid of significant cholinergic properties.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027724085&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0027724085
VL - 30
SP - 1357
EP - 1359
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - 5
ER -