Synthesis of a new series of N-substituted-3-[1-alkyl(aryl)-4- piperidyl]azetidin-2-ones as possible muscarinic agents

G. Cignarella, S. Villa, D. Barlocco

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Abstract

A new series of N-substituted-3-[1-alkyl(aryl)-4-piperidyl]azetidin-2- ones 2a-j structurally related to the previously reported 2,7- diazaspiro[3,5]nonan-1-ones 1 have been synthesized and tested for their activity as muscarinic agents, both in vitro and in vivo. Preliminary pharmacological results showed that compounds 2 are devoid of significant cholinergic properties.

Original languageEnglish
Pages (from-to)1337-1340
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume30
Issue number5
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Organic Chemistry

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