Synthesis of a novel class of gem-phosphonate-phosphates by reductive cleavage of the isoxazolidine ring

Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo, Donatella Granchi

Research output: Contribution to journalArticle

Abstract

A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalCurrent Organic Synthesis
Volume11
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Apolipoprotein E
  • Bisphosphonates
  • Gem-phosphonate-phosphate rearrangement
  • Isoxazolidines
  • Ring opening
  • Transition-metal carbonyls

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

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