Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly)

R. Galeazzi, E. Marcucci, G. Martelli, D. Natali, M. Orena, S. Rinaldi

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z 2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalAmino Acids
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Amino acids
  • Conformational restriction
  • Lactams
  • Mimetics
  • Orthogonal protection

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

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