Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly)

R. Galeazzi, E. Marcucci, G. Martelli, D. Natali, M. Orena, S. Rinaldi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z 2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalAmino Acids
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

aspartylglycine
Lactams
Dipeptides
Alkylation
N-benzyloxycarbonylglycine

Keywords

  • Amino acids
  • Conformational restriction
  • Lactams
  • Mimetics
  • Orthogonal protection

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

Cite this

Galeazzi, R., Marcucci, E., Martelli, G., Natali, D., Orena, M., & Rinaldi, S. (2008). Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly). Amino Acids, 34(2), 333-336. https://doi.org/10.1007/s00726-006-0469-9

Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly). / Galeazzi, R.; Marcucci, E.; Martelli, G.; Natali, D.; Orena, M.; Rinaldi, S.

In: Amino Acids, Vol. 34, No. 2, 02.2008, p. 333-336.

Research output: Contribution to journalArticle

Galeazzi, R, Marcucci, E, Martelli, G, Natali, D, Orena, M & Rinaldi, S 2008, 'Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly)', Amino Acids, vol. 34, no. 2, pp. 333-336. https://doi.org/10.1007/s00726-006-0469-9
Galeazzi, R. ; Marcucci, E. ; Martelli, G. ; Natali, D. ; Orena, M. ; Rinaldi, S. / Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly). In: Amino Acids. 2008 ; Vol. 34, No. 2. pp. 333-336.
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