Abstract
The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z 2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
Original language | English |
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Pages (from-to) | 333-336 |
Number of pages | 4 |
Journal | Amino Acids |
Volume | 34 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2008 |
Keywords
- Amino acids
- Conformational restriction
- Lactams
- Mimetics
- Orthogonal protection
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry
- Endocrinology