Abstract
The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z 2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
| Original language | English |
|---|---|
| Pages (from-to) | 333-336 |
| Number of pages | 4 |
| Journal | Amino Acids |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2008 |
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Keywords
- Amino acids
- Conformational restriction
- Lactams
- Mimetics
- Orthogonal protection
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry
- Endocrinology
Cite this
Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly). / Galeazzi, R.; Marcucci, E.; Martelli, G.; Natali, D.; Orena, M.; Rinaldi, S.
In: Amino Acids, Vol. 34, No. 2, 02.2008, p. 333-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly)
AU - Galeazzi, R.
AU - Marcucci, E.
AU - Martelli, G.
AU - Natali, D.
AU - Orena, M.
AU - Rinaldi, S.
PY - 2008/2
Y1 - 2008/2
N2 - The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z 2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
AB - The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z 2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
KW - Amino acids
KW - Conformational restriction
KW - Lactams
KW - Mimetics
KW - Orthogonal protection
UR - http://www.scopus.com/inward/record.url?scp=39049094111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049094111&partnerID=8YFLogxK
U2 - 10.1007/s00726-006-0469-9
DO - 10.1007/s00726-006-0469-9
M3 - Article
C2 - 17136507
AN - SCOPUS:39049094111
VL - 34
SP - 333
EP - 336
JO - Amino Acids
JF - Amino Acids
SN - 0939-4451
IS - 2
ER -