Synthesis of dihydrolysergol analogues

S. Mantegani, G. Traquandi, M. Varasi

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Abstract

As a part of a search for novel biological active ergoline derivatives, the indole ring present in the ergoline skeleton (indole[4,3-f,g]quinoline) was converted into different heterocyclic ring systems such as quinazoline 2, benzofurane 3 and benzoxazole 4. Due to the paramount importance of chirality to attain biological activity, natural dihydrolysergic acid 1 was chosen as starting material and a synthetic pathway conservative in term of chirality was followed.

Original languageEnglish
Pages (from-to)759-763
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume38
Issue number3
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Organic Chemistry

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Mantegani, S., Traquandi, G., & Varasi, M. (2001). Synthesis of dihydrolysergol analogues. Journal of Heterocyclic Chemistry, 38(3), 759-763.