As a part of a search for novel biological active ergoline derivatives, the indole ring present in the ergoline skeleton (indole[4,3-f,g]quinoline) was converted into different heterocyclic ring systems such as quinazoline 2, benzofurane 3 and benzoxazole 4. Due to the paramount importance of chirality to attain biological activity, natural dihydrolysergic acid 1 was chosen as starting material and a synthetic pathway conservative in term of chirality was followed.
|Number of pages||5|
|Journal||Journal of Heterocyclic Chemistry|
|Publication status||Published - 2001|
ASJC Scopus subject areas
- Organic Chemistry