Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging

Ilaria Monaco, Francesca Arena, Stefania Biffi, Erica Locatelli, Barbara Bortot, Francesca La Cava, Giada Maria Marini, Giovanni Maria Severini, Enzo Terreno, Mauro Comes Franchini

Research output: Contribution to journalArticle

Abstract

In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.

Original languageEnglish
Pages (from-to)1382-1390
Number of pages9
JournalBioconjugate Chemistry
Volume28
Issue number5
DOIs
Publication statusPublished - May 17 2017

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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