Synthesis of new allyl palladium complexes bearing purine-based NHC ligands with antiproliferative and proapoptotic activities on human ovarian cancer cell lines

Thomas Scattolin, Isabella Caligiuri, Luciano Canovese, Nicola Demitri, Roberto Gambari, Ilaria Lampronti, Flavio Rizzolio, Claudio Santo, Fabiano Visentin

Research output: Contribution to journalArticlepeer-review

Abstract

A series of new palladium allyl complexes bearing purine-based carbenes derived from caffeine, theophylline and theobromine have been prepared and characterized by NMR spectroscopy, and elemental analysis and in two cases by single crystal X-ray diffraction. The cytotoxic and proapoptotic activities of compounds have been determined in vitro on human ovarian cancer A2780 and SKOV-3 cell lines. These experiments have shown that the palladium-allyl fragment induces a general cytotoxicity, but the choice of the supporting ligands is of paramount importance for achieving the best results. In particular complexes 4c, 4d and 5d exhibit a higher antiproliferative effect (IC50: 0.09, 0.81 and 0.85 μM respectively) than cisplatin (IC50: 1.5 μM) on A2780 cells, and 4d (IC50: 1.7 μM vs. 5.94 μM) on SKOV-3 cell line. Moreover in many cases it has been proved that the cytotoxicity of our complexes is associated with the induction of apoptosis.

Original languageEnglish
Pages (from-to)13616-13630
Number of pages15
JournalDalton Transactions
Volume47
Issue number38
DOIs
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Inorganic Chemistry

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