Synthesis of new cytotoxic E-ring modified camptothecins

Salvatore Cananzi, Sabrina Dallavalle, Alberto Bargiotti, Lucio Merlini, Roberto Artali, Giovanni Luca Beretta

Research output: Contribution to journalArticlepeer-review

Abstract

In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.

Original languageEnglish
Pages (from-to)6489-6492
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number50
DOIs
Publication statusPublished - Dec 15 2010

Keywords

  • Antitumour activity
  • Camptothecin
  • Molecular docking
  • Synthesis
  • Topoisomerase 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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