Abstract
In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.
Original language | English |
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Pages (from-to) | 6489-6492 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 50 |
DOIs | |
Publication status | Published - Dec 15 2010 |
Keywords
- Antitumour activity
- Camptothecin
- Molecular docking
- Synthesis
- Topoisomerase 1
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery