Synthesis of new cytotoxic E-ring modified camptothecins

Salvatore Cananzi, Sabrina Dallavalle, Alberto Bargiotti, Lucio Merlini, Roberto Artali, Giovanni Luca Beretta

Research output: Contribution to journalArticlepeer-review


In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.

Original languageEnglish
Pages (from-to)6489-6492
Number of pages4
JournalTetrahedron Letters
Issue number50
Publication statusPublished - Dec 15 2010


  • Antitumour activity
  • Camptothecin
  • Molecular docking
  • Synthesis
  • Topoisomerase 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


Dive into the research topics of 'Synthesis of new cytotoxic E-ring modified camptothecins'. Together they form a unique fingerprint.

Cite this